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Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: definitions and current practice in Europe

Bone Marrow Transplantation volume 37, pages 439–449 (2006)Cite this article

Abstract

The Accreditation Subcommittee of the EBMT regularly publishes special reports on current practice of haemopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders in Europe. Major changes have occurred since the first report was published in 1996. Haemopoietic stem cell transplantation today includes grafting with allogeneic and autologous stem cells derived from bone marrow, peripheral blood and cord blood. With reduced intensity conditioning regimens in allogeneic transplantation, the age limit has increased, permitting the inclusion of older patients. New indications have emerged such as autoimmune disorders and AL amyloidosis for autologous, and solid tumours for allogeneic transplants. The introduction of alternative therapies has challenged well-established indications such as imatinib for chronic myeloid leukaemia. An updated report with revised tables and operating definitions is presented here.

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Acknowledgements

We are grateful for the advice and helpful comments received from a number of individuals across Europe, specialising in the use of haemopoietic stem cell transplantation to treat patients with haematological disorders. We extend special thanks to G Gahrton, R Willemze, J Esteve, H Dombret, P Corradini, P Dreger, C Gisselbrecht, M Trneny, H Greinix, Y Beguin, CG Steward, A Fischer, A Cant, L Notarangelo, W Friedrich, and N Wulffraat.

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Authors and Affiliations

  1. Department of Hematology, Karolinska University Hospital, Stockholm, Sweden

    P Ljungman

  2. Hospital Clinic, Barcelona, Spain

    A Urbano-Ispizua

  3. Department of Biotherapy, Hopital Necker, Paris, France

    M Cavazzana-Calvo

  4. Department of Hematology/Oncology, Ibn-i Sina Hospital, Ankara University Medical School, Ankara, Turkey

    T Demirer

  5. Department of Paediatric Haematology and Oncology, IRCCS ‘G.Gaslini’, Genoa, Italy

    G Dini

  6. Department of Hematology and Oncology, University of Würzburg, Würzburg, Germany

    H Einsele

  7. Hematology division, University Hospital, Basel, Switzerland

    A Gratwohl

  8. Anthony Nolan Bone Marrow Trust, Royal Free Hospital, London, UK

    A Madrigal

  9. Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany

    D Niederwieser

  10. Hematology Division, Geneva University Hospital, Geneva, Switzerland

    J Passweg

  11. Department of Hematology, BMT Unit, Hopital St Louis, Paris, France

    V Rocha & G Socie

  12. Department Hematology, Careggi Hospital & University of Florence, Florence, Italy

    R Saccardi

  13. Department of Internal Medicine, section of Hematology-Oncology, Maastricht, The Netherlands

    H Schouten

  14. Department of Hematology, AK St Georg, Hamburg, Germany

    N Schmitz

  15. Clinical Hematology Division, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

    A Sureda

  16. Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London, UK

    J Apperley

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  1. P Ljungman
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  2. A Urbano-Ispizua
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  3. M Cavazzana-Calvo
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  6. H Einsele
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  7. A Gratwohl
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  8. A Madrigal
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  9. D Niederwieser
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  10. J Passweg
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  11. V Rocha
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  12. R Saccardi
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  13. H Schouten
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  14. N Schmitz
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  15. G Socie
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  16. A Sureda
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  17. J Apperley
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for the European Group for Blood and Marrow Transplantation

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Correspondence to P Ljungman.

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Ljungman, P., Urbano-Ispizua, A., Cavazzana-Calvo, M. et al. Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: definitions and current practice in Europe. Bone Marrow Transplant 37, 439–449 (2006). https://doi.org/10.1038/sj.bmt.1705265

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  • DOI: https://doi.org/10.1038/sj.bmt.1705265

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