Mitochondrial fission-fusion and trafficking are altered in the fatal neurodegenerative disorder Huntington's disease. Huntingtin is now shown to function directly in these processes by binding the mitochondrial fission factor dynamin-related protein-1 (DRP1). Mutant huntingtin binds more tightly to DRP1, leading to increased mitochondrial fission and neuronal death, highlighting DRP1 as a potential therapeutic target in Huntington's disease (pages 377–382).
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Change history
07 April 2011
In the version of this article initially published, the first author of the primary paper that the N&V referred to was incorrectly cited as Petrilli. The correct first author is Song. The error has been corrected in the HTML and PDF versions of the article.
07 April 2011
In the version of this article initially published, the authors omitted to mention that L. Scorrano and colleagues had previously shown increased Drp1 activity and mitochondrial fission in cellular models of Huntington’s disease and would now like to cite this work (EMBO Mol. Med. 2, 490–503, 2010). The error has been corrected in the HTML and PDF versions of the article.
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Johri, A., Chaturvedi, R. & Beal, M. Hugging tight in Huntington's. Nat Med 17, 245–246 (2011). https://doi.org/10.1038/nm0311-245
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DOI: https://doi.org/10.1038/nm0311-245
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