Circadian control depends on oscillating transcription factors, master switches synchronized by stimuli such as light and feeding. Recent studies show that altering circadian rhythmicity also results in pathophysiological changes resembling the metabolic syndrome.
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Staels, B. When the Clock stops ticking, metabolic syndrome explodes. Nat Med 12, 54–55 (2006). https://doi.org/10.1038/nm0106-54
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DOI: https://doi.org/10.1038/nm0106-54
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