Regulation of organ size is achieved through the action of the mTOR and Hippo signalling pathways, which control cell proliferation and cell growth in response to extracellular cues. A link between these pathways is revealed by the finding that YAP downregulates PTEN to promote cell growth and tissue hyperplasia.
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Csibi, A., Blenis, J. Hippo–YAP and mTOR pathways collaborate to regulate organ size. Nat Cell Biol 14, 1244–1245 (2012). https://doi.org/10.1038/ncb2634
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DOI: https://doi.org/10.1038/ncb2634
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