Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Hippo–YAP and mTOR pathways collaborate to regulate organ size

Regulation of organ size is achieved through the action of the mTOR and Hippo signalling pathways, which control cell proliferation and cell growth in response to extracellular cues. A link between these pathways is revealed by the finding that YAP downregulates PTEN to promote cell growth and tissue hyperplasia.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Interplay between the mTOR and Hippo signalling pathways through miR-29 to control organ size.

References

  1. Tumaneng, K., Russell, R. C & Guan, K. L. Curr. Biol 22, R368–379 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Ma, X. M. & Blenis, J. Nat. Rev. Mol. Cell Biol. 10, 307–318 (2009).

    Article  PubMed  Google Scholar 

  3. Laplante, M. & Sabatini, D. M. Cell 149, 274–293 (2012).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Ramos, A. & Camargo, F. D. Trends Cell Biol. 22, 339–346 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Ye, X., Deng, Y & Lai, Z. C. Dev. Biol. 369, 115–123 (2012).

    Article  CAS  PubMed  Google Scholar 

  6. Straβburger, K. et al. Dev. Biol. 367, 187–196 (2012).

    Article  Google Scholar 

  7. Tumaneng, K. et al. Nat. Cell Biol. 14, 1322–1329 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Gwinn, D. M. et al. Mol. Cell 30, 214–226 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Kim, S. G. et al. Mol. Cell http://dx.doi.org/10.1016/j.molcel.2012.10.003 (2012).

  10. Sancak, Y. et al. Cell 141, 290–303 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Pan, D. Dev. Cell 19, 491–505 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Yu, F. X. et al. Cell 150, 780–791 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Mo, J. S., Yu, F. X., Gong, R., Brown, J. H. & Guan, K. L. Genes Dev. 26, 2138–2143 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Zhao, B. et al. Genes Dev. 21, 2747–2761 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Zhou, L. et al. PLoS One 7, e33766 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John Blenis.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Csibi, A., Blenis, J. Hippo–YAP and mTOR pathways collaborate to regulate organ size. Nat Cell Biol 14, 1244–1245 (2012). https://doi.org/10.1038/ncb2634

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb2634

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing