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The cellular neurobiology of depression

Nature Medicine volume 7, pages 541–547 (2001)Cite this article

Abstract

Major depressive disorders, long considered to be of neurochemical origin, have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways may hold promise as new therapeutics for depression.

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Figure 1: Anatomical circuits implicated by neuroimaging and neuropathological studies of familial mood disorders.
Figure 2: Neuroplasticity and cellular resilience in mood disorders.

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Acknowledgements

We thank R.S. Duman for valuable comments and input; G. Rajkowska for help in generating Table 2; and C. Knobelsdorf for editorial assistance.

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Authors and Affiliations

  1. Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, Maryland, USA

    Husseini K. Manji

  2. Section on Neuroimaging, National Institute of Mental Health, Bethesda, Maryland, USA

    Wayne C. Drevets

  3. Mood and Anxiety Disorders Research Program, National Institute of Mental Health, Bethesda, Maryland, USA

    Dennis S. Charney

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  1. Husseini K. Manji
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  2. Wayne C. Drevets
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  3. Dennis S. Charney
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Correspondence to Husseini K. Manji.

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Manji, H., Drevets, W. & Charney, D. The cellular neurobiology of depression. Nat Med 7, 541–547 (2001). https://doi.org/10.1038/87865

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