Abstract
The nucleotide sequence of cloned cDNA for preproenkephalin from bovine adrenal medulla indicates that the precursor protein contains four copies of Met-enkephalin and one copy each of Leu-enkephalin, Met-enkephalin-Arg6 -Phe7 and Met-enkephalin-Arg6 -Gly7 -Leu8, a previously undetected opioid peptide. The enkephalin and extended enkephalin sequences are each bounded by paired basic amino acid residues. Preproenkephalin may represent a multi-hormone precursor, like the corticotropin-β-lipotropin precursor.
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Noda, M., Furutani, Y., Takahashi, H. et al. Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin. Nature 295, 202–206 (1982). https://doi.org/10.1038/295202a0
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DOI: https://doi.org/10.1038/295202a0
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