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Benzodiazepine receptors in rat brain

Abstract

HIGH affinity binding of tritium labelled morphine and morphine-like drugs to membranes in brain homogenates1–3 was a decisive advance in the characterisation of opiate receptors and the discovery of enkephalines and endorphines. We report here experiments which suggest that another important group of psychoactive drugs, the benzodiazepines, bind to specific receptors on the membranes of rat brain cells. This suggests that there may be an unknown endogenous neurotransmitter which is the natural ligand for the benzodiazepine receptor. The binding sites are distributed unevenly through the brain, and displacement potencies of benzodiazepines correlate with pharmacological effects predictive of anxiolytic activity.

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References

  1. Pert, C. B. & Snyder, S. H. Science 179, 1011–1014 (1973).

    Article  ADS  CAS  Google Scholar 

  2. Simon, E. J., Hiller, J. M. & Edelman, I. Proc. natn. Acad. Sci. U.S.A. 70, 1947–1949 (1973).

    Article  ADS  CAS  Google Scholar 

  3. Terenius, L. Acta pharmacol. Toxicol. 32, 317–320 (1973).

    Article  CAS  Google Scholar 

  4. Olds, M. E. & Olds, J. Int. J. Neuropharm. 8, 87–103 (1969).

    Article  CAS  Google Scholar 

  5. Cuatrecasas, P. Adv. Cyclic Nucleotide Res. 5, 79–104 (1975).

    CAS  PubMed  Google Scholar 

  6. Randall, L. O., Schallek, W., Sternbach, L. H. & Ning, R. Y. Psychopharmacological Agents 3, (ed. Maxwell Gordon) 175–281 (Academic, New York, 1974).

    Book  Google Scholar 

  7. Young, A. B., Zukin, S. R. & Snyder, S. H. Proc. natn. Acad. Sci. U.S.A. 71, 2246–2250 (1974).

    Article  ADS  CAS  Google Scholar 

  8. Curtis, D. R., Game, C. J. A. & Lodge, D. Br. J. Pharmac. 56, 307–311 (1976).

    Article  CAS  Google Scholar 

  9. Dray, A. & Straughan, D. W. J. pharm. Pharmac. 28, 314–315 (1976).

    Article  CAS  Google Scholar 

  10. Snyder, S. H. & Enna, S. J. Adv. biochem. Psychopharmac. 14, 81–93 (1975).

    CAS  Google Scholar 

  11. Haefely, W. et al. in Mechanism of Action of Benzodiazepines (eds Costa, E. & Greengard, P.) 131–151 (Raven, New York, 1975).

    Google Scholar 

Download references

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SQUIRES, R., BRAESTRUP, C. Benzodiazepine receptors in rat brain. Nature 266, 732–734 (1977). https://doi.org/10.1038/266732a0

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