Abstract
MARIJUANA produces differential effects in human naive and experienced marijuana smokers1, but owing to ethical constraints involved in repeatedly administering marijuana to drug-naive humans, many human experiments have involved only experienced marijuana users as subjects. These constraints, however, are minimal with non-human subjects, and the great majority of animals used in marijuana research have been drug naive. So far, distinguishing between the long-term effects of marijuana in drug-naive and drug-experienced animal subjects has little precedence in the literature. We report here a number of observations, made over a two-year period during our marijuana research with chimpanzees, which indicate that experiential factors may play a major role in the effects of marijuana on complex behaviour.
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References
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GRILLY, D., FERRARO, D. & MARRIOTT, R. Long-term Interactions of Marijuana and Behaviour in Chimpanzees. Nature 242, 119–120 (1973). https://doi.org/10.1038/242119a0
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DOI: https://doi.org/10.1038/242119a0
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