REFERENCES
G. J. Dutton. Glucuronidation of Drugs and Other Compounds, CRC Press, Boca Raton, FL, 1980, pp. 3–78.
T. R. Tephly and B. Burchell. UDP-glucuronosyltransferases: A family of detoxifying enzymes. Trends Pharmacol. Sci. 11:276–279 (1990).
B. Burchell, D. W. Nebert, D. R. Nelson, K. W. Bock, T. Iyanagi, P. L. M. Jansen, D. Lancet, G. J. Mulder, J. R. Chowdhury, G. Siest, T. R. Tephly, and P. I. Mackenzie. The UDP glucuronosyltransferase gene superfamily: Suggested nomenclature based on evolutionary divergence. DNA Cell Biol 10:487–494 (1991).
T. N. Wight and R. P. Mecham. Biology of Proteoglycans, Academic Press, Orlando, FL, 1987.
A. W. Wolkoff, J. Roy Chowdhury, and I. M. Arias. Hereditary jaundice and disorders of bilirubin metabolism. In C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle (eds.), The Metabolic Basis of Inherited Disease, McCraw-Hill, New York, 1987, pp. 1367–1408.
P. I. Mackenzie. Rat liver UDP-glucuronosyltransferase: Sequence and expression of a cDNA encoding a phenobarbitalinducible form. J. Biol. Chem. 261:6119–6125 (1986).
P. I. Mackenzie. Rat liver UDP-glucuronosyltransferase: cDNA sequence and expression of a form glucuronidating 3-hydroxyandrogens. J. Biol. Chem. 261:14112–14117 (1986).
T. Iyanagi, M. Haniu, K. Sogawa, Y. Fuji-Kuriyama, S. Watanabe, J. E. Shivey, and K. F. Anan. Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase. J. Biol. Chem. 261:15607–15614 (1986).
P. I. Mackenzie. Rat liver UDP-glucuronosyltransferase: Identification of cDNAs encoding two enzymes which glucuronidate testosterone, dihydrotestosterone, and β-estradiol. J. Biol. Chem. 262:9744–9749 (1987).
D. Harding, S. M. Wilson, M. R. Jackson, B. Burchell, M. D. Green, and T. R. Tephly. Nucleotide and deduced amino acid sequence of rat liver 17β-hydroxysteroid UDP-glucuronosyltransferase. Nucl. Acid Res. 15:936 (1987).
H. Sato, O. Koiwai, K. Tanabe, and S. Kashiwamata. Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: Possible alternative splicing of a common primary transcript. Biochem. Biophys. Res. Commun. 169:260–264 (1990).
P. I. Mackenzie. The cDNA sequence and expression of a variant 17β-hydroxysteroid UDP-glucuronosyltransferase. J. Biol. Chem. 265:8699–8703 (1990).
D. Lazard, K. Zupko, Y. Poria, P. Nef, J. Lazarovits, S. Horn, M. Khen, and D. Lancet. Odorant signal termination by olfactory UDP-glucuronosyltransferase. Nature 349:790–793 (1991).
M. R. Jackson, L. R. McCarthy, D. Harding, S. Wilson, M. W. H. Coughtrie, and B. Burchell. Cloning of human liver microsomal UDP-glucuronosyltransferase cDNA. Biochem. J. 242:581–588 (1987).
D. Harding, S. Fournel-Gigleux, M. R. Jackson, and B. Burchell. Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells. Proc. Natl. Acad. Sci. 85:8381–8385 (1988).
J. K. Ritter, Y. Y. Sheen, and I. S. Owens. Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. J. Biol. Chem. 265:7900–7906 (1990).
J. K. Ritter, J. M. Crawford, and I. S. Owens. Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells. J. Biol. Chem. 266:1043–1047 (1991).
R. Wooster, L. Sutherland, T. Ebner, D. Clarke, O. Da Cruze e Silva, and B. Burchell. Cloning and stable expression of a new member of the human phenol/bilirubin UDP-glucuronosyltransferase cDNA family. Biochem. J. 278:465–469 (1991).
T. Kimura and I. S. Owens. Mouse UDP-glucuronosyltransferase: cDNA and complete amino acid sequence and regulation. Eur. J. Biochem. 168:515–521 (1987).
N. Malik and I. S. Owens. Genetic regulation of bilirubin-UDP-glucuronosyltransferase induction by polycyclic aromatic compounds and phenobarbital in mice. J. Biol. Chem. 256:9599–9604 (1981).
A.-N. T. Kong, L. Yang, M. Ma, D. Tao, and T. D. Bjornsson. Molecular cloning of the alcohol/hydroxysteroid form (hST a) of sulfotransferase from human liver. Biochem. Biophys Res. Commun. 187:448–454 (1992).
F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (eds.). Current Protocols in Molecular Biology, Greene, New York, 1989.
A. P. Feinberg and B. Vogelstein. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6–13 (1983).
F. Sanger, S. Nicklen, and A. R. Coulson. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463–5467 (1977).
A.-N. T. Kong, M. Ma, and I. S. Owens. Molecular cloning of a mouse bilirubin/phenol UDP-glucuronosyltransferase (UGT Br). J. Clin. Pharmacol. 32:762 (1992).
M. E. E. Watson. Compilation of published signal sequence. Nucl. Acid Res. 12:5145–5164 (1984).
T. K. Rose, W. J. Welse, B. M. Sefton, F. S. Esch, and N. C. Ling. Vesicular stomatitis virus glycoprotein is anchored in the viral membrane by a hydrophobic domain near the COOH terminus. Proc. Natl. Acad. Sci. 77:3884–3888 (1980).
J. K. Ritter, F. Chen, Y. Y. Sheen, H. M. Tran, S. Kimura, M. T. Yeatman, and I. S. Owens. A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. J. Biol. Chem. 267:3257–3261 (1992).
W. Lilienblum and K. W. Bock. N-Glucuronide formation of carcinogenic aromatic amines in rat and human liver microsomes. Biochem. Pharmacol. 33:2041–2046 (1984).
M. D. Green and T. R. Tephly. N-Glucuronidation of carcinogenic aromatic amines catalyzed by rat hepatic microsomal preparations and purified rat liver uridine 5′-diphosphate-glucuronosyltransferase. Cancer Res. 47:2028–2031 (1987).
P. C. Smith, A. F. McDonagh, and L. Z. Benet. Irreversible binding of zomepirac to plasma protein in vitro and vivo. J. Clin. Invest. 77:934–939 (1986).
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Kong, AN.T., Ma, M., Tao, D. et al. Molecular Cloning of Two cDNAs Encoding the Mouse Bilirubin/Phenol Family of UDP-Glucuronosyltransferases (mUGT Br/p). Pharm Res 10, 461–465 (1993). https://doi.org/10.1023/A:1018965011846
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DOI: https://doi.org/10.1023/A:1018965011846