Review
New treatment regimes for virus-induced exacerbations of asthma

https://doi.org/10.1016/j.pupt.2005.09.005Get rights and content

Abstract

This review will focus on the role of viruses as causes of asthma exacerbations. The article will briefly review the current literature supporting this view, with a special focus on human rhinovirus (RV), the main virus associated with exacerbations of asthma. The review will then refer to possible strategies for treatment, and will include discussion on treatment with specific anti-viral therapy and type I interferon as a treatment for RV. The review will also include a discussion on current therapies for asthma, such as glucocorticosteroid and β2 agonist therapy alone and in combination and why this may be relevant to virus-induced exacerbations of asthma. Finally, the potential for future anti-inflammatory/immunomodulatory therapies with a focus on NF-κB inhibition will be discussed.

Keywords

Rhinovirus
Asthma
Therapy
NF-κB
Lung
Steroid
Interferon

Abbreviations

RSV
respiratory syncytial virus
RV
rhinovirus
IFN
interferon
COPD
chronic obstructive pulmonary disease
NIK
NF-κB inducing kinase
IKK
IκB kinase
TBK
TANK binding kinase
PKR
anti-viral protein kinase
TLR3
Toll-like receptor 3
RIG
retinoic acid inducible gene
MIC
minimum inhibitory concentration
GCs
glucocorticoids
GR
glucocorticoid receptor
LABA
long-acting β2 agonists

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