Local administration of a cannabinoid agonist alters norepinephrine efflux in the rat frontal cortex
Section snippets
Acknowledgements
The authors acknowledge the technical assistance of Ms. Y. Qian and Ms. M.L. Livingstone Supported by NIDA DA 020129, DA 15395 and V.O. was supported by a Minority Student Supplement to DA 09082 from NIDA.
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2019, Neurobiology of StressCitation Excerpt :Additionally, electron microscopy studies have shown that CB1r are found on both glutamatergic and GABAergic presynaptic axon terminals that synapse with NE-producing LC neurons as well as post-synaptically in somatodendritic processes of LC cells (Scavone et al., 2010). The presence of CB1r on LC-NE neurons is functional, as indicated by electrophysiological studies showing that CB1r agonists and FAAH inhibitors increase the basal firing rate of LC-NE cells, c-Fos expression of LC neurons, and NE efflux in the mPFC (Gobbi et al., 2005; Oropeza et al., 2005; Mendiguren and Pineda, 2006; Muntoni et al., 2006; Page et al., 2008). The eCB system also regulates NE microcircuits in LC target regions.