Cell Metabolism
Volume 15, Issue 6, 6 June 2012, Pages 838-847
ArticleThe NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
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Highlights
► NR efficiently increases NAD+ levels in mammalian cells and tissues ► NR supplementation increases SIRT1 and SIRT3 activities ► NR largely prevents the detrimental metabolic effects of high-fat feeding ► NR enhances mitochondrial function and endurance performance
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These authors contributed equally to this work
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Present address: Nestlé Institute of Health Sciences, CH-1015 Lausanne, Switzerland
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Present address: Laboratory Genetic Metabolic Diseases, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
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