Novel 2-imidazoles as potent and selective α1A adrenoceptor partial agonists
Graphical abstract
A series of novel 2-imidazoles is described, which combine potent and selective α1A partial agonist pharmacology with good drug-like properties.
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Acknowledgments
We thank Alison Bridgeland for screening data; Debbie Lovering, Edward Pegden, Danny Ho, Katherine England and Helen Mason for compound synthesis. We also thank Peter Bungay for ADME assessment of compound 23.
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