Archival ReportKetamine as a Prophylactic Against Stress-Induced Depressive-like Behavior
Section snippets
Mice
Male 129S6/SvEvTac mice were purchased from Taconic (Hudson, New York). CD-1 mice were purchased from Charles River Laboratories (Wilmington, Massachusetts) at 8 to 10 weeks of age and housed individually until the start of SD. The procedures described herein were conducted in accordance with the National Institutes of Health regulations and approved by the Institutional Animal Care and Use Committees of Columbia University and the New York State Psychiatric Institute.
Male C57BL/6NTac mice were
Ketamine Administration Before SD Protects Against the Induction of Depressive-like Behavior
Mice were administered a single injection of saline or ketamine (30 mg kg−1) (Figure 1A). One week later, mice either remained group housed (Ctrl) or underwent SD. After 2 weeks of SD, mice were weighed (Supplemental Figure S2A), and behavior was assessed.
Classically, immobility in the FST has been interpreted as an index of hopelessness or a negative mood (31). Rodents given acute or chronic antidepressants exhibit decreased immobility (32). Here, on day 2 of the FST, there was an overall
Discussion
Here, we have shown that a single injection of ketamine administered before SD protected mice against stress-induced increased immobility time in the FST. Additionally, ketamine protected mice against stress-induced social avoidance of an aggressor mouse. We found that mice administered ketamine before SD were protected against stress-induced depressive-like behavior, but consistent with the literature definition of stress resilience, their behavior in anxiety tests and levels of adult
Acknowledgments and Disclosures
RAB was supported by National Institute of Child Health and Human Development Grant No. T32HD07430. DJD currently was supported by Lundbeck and the Brain & Behavior Research Foundation (formerly National Alliance for Research on Schizophrenia and Depression). The lab UMR S 1178 is funded by Agence Nationale pour la Recherche SAMENTA (Grant No. ANR-12-SAMA-0007). RH was supported by Grant Nos. R37 MH068542 and R01 AG043688, and a Hope for Depression Research Foundation grant. CAD was supported
References (45)
- et al.
Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions
Cell
(2007) - et al.
Effects of striatal deltaFosB overexpression and ketamine on social defeat stress-induced anhedonia in mice
Biol Psychiatry
(2014) - et al.
PACAP-deficient mice show attenuated corticosterone secretion and fail to develop depressive behavior during chronic social defeat stress
Psychoneuroendocrinology
(2013) - et al.
Implications of failing to achieve successful long-term maintenance treatment of recurrent unipolar major depression
Biol Psychiatry
(1998) - et al.
Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression
Biol Psychiatry
(2013) - et al.
Ketamine infusions: Pharmacokinetics and clinical effects
Br J Anaesth
(1979) - et al.
Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis
Neuron
(2014) - et al.
Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
Neuron
(2009) - et al.
Overlapping neurobiology of learned helplessness and conditioned defeat: Implications for PTSD and mood disorders
Neuropharmacology
(2012) - et al.
Behavioral alterations and pro-oxidant effect of a single ketamine administration to mice
Brain Res Bull
(2010)
Invisible Wounds of War: Summary and Recommendations for Addressing Psychological and Cognitive Injuries
Neurobiology of resilience
Nat Neurosci
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
Nat Neurosci
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Nature
Infantile experience and resistance to physiological stress
Science
Stress inoculation-induced indications of resilience in monkeys
J Trauma Stress
Promoting psychological resilience in the U.S. military
Physical exercise prevents stress-induced activation of granule neurons and enhances local inhibitory mechanisms in the dentate gyrus
J Neurosci
Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress
Mol Psychiatry
Environmental enrichment confers stress resiliency to social defeat through an infralimbic cortex-dependent neuroanatomical pathway
J Neurosci
Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis
J Neurosci
Lymphocytes from chronically stressed mice confer antidepressant-like effects to naïve mice
J Neurosci
Cited by (171)
A role of gut–brain axis on prophylactic actions of arketamine in male mice exposed to chronic restrain stress
2024, Pharmacology Biochemistry and BehaviorThe Psychoneuroimmunological Model of Moral Distress and Health in healthcare workers: Toward individual and system-level solutions
2024, Comprehensive PsychoneuroendocrinologyRole of stress in skin diseases: A neuroendocrine-immune interaction view
2024, Brain, Behavior, and ImmunityJiawei-Xiaoyao pill elicits a rapid antidepressant effect, dependent on activating CaMKII/mTOR/BDNF signaling pathway in the hippocampus
2024, Journal of EthnopharmacologySex-Specific Alterations in Spatial Memory and Hippocampal AKT-mTOR Signaling in Adult Mice Pre-exposed to Ketamine and/or Psychological Stress During Adolescence
2024, Biological Psychiatry Global Open Science