Synthesis of RPR 100893, prototype of a new series of potent and selective non peptide NK1 antagonists : the triarylperhydroisoindolols.

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Abstract

The synthesis of enentiomerically pure RPR 100893, a novel non peptide NK1 Substance P antagonist, is described. This compound is a representative of 7,7,4-triaryl perhydroisoindol-4-ols, a new series of perhydroisoindole Substance P antagonists with high affinity for human NK1 receptor.

The synthesis of RPR 100893, a non peptide substance P antagonist with higher affinity for human NK1 receptor is described.

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