Neurotransmitter-gated ion channels as unconventional allosteric proteins

doi:10.1016/S0959-440X(94)90218-6

Current Opinion in Structural Biology

Volume 4, Issue 4, 1994, Pages 554-565

https://doi.org/10.1016/S0959-440X(94)90218-6 Get rights and content

Abstract

Biochemical, mutagenesis and electron microscopy investigations of neurotransmitter receptors linked with ion channels result in a map of the neurotransmitter binding site and the ion channel at the amino acid level. The data are consistent with the view that these quasi-symmetrical hetero-oligomers are allosteric proteins, yet with distinctive features associated with their transmembrane disposition.

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Neurotransmitter-gated ion channels as unconventional allosteric proteins

Abstract

J Memb Biol

Ann Rev Neurosci

J Mol Biol

Mol Neurobiol

J Neurochem

J Neurosci

Neuron

J Biol Chem

J Biol Chem

Nature

J Biol Chem

Biophys J

J Biol Chem

Neuron

Biochemistry

Biochemistry

Neuron

Neuron

Biophys J

Biochemistry

Biochemistry

J Biol Chem

Science

A Study of the Desensitization Produced by Acetylcholine at the Motor End-Plate

J Physiol

Single Acetylcholine-Activated Channels Show Burst-Kinetics in Presence of Desensitizing Concentrations of Agonist

Nature

Functional Architecture and Dynamics of the Nicotinic Acetylcholine Receptor: An Allosteric Ligand-Gated Ion Channel

Structure and Function of Inhibitory Glycine Receptors

Quarterly Rev Biophys

The Diversity of Neuronal Nicotinic Acetylcholine Receptors

Ann Rev Neurosci

Diversity in Primary Structure and Function of Neuronal Nicotinic Acetylcholine Receptor Channels

Curr Opin Neurobiol

Structure of Nicotinic Acetylcholine Receptors

Curr Opin Neurobiol

The Molecular Biology of Mammalian Glutamate Receptor Channels

Trends Neurosci

On the Nature of Allosteric Transitions: A Plausible Model

J Mol Biol

Mechanisms of Cooperativity and Allosteric Regulation in Proteins

Quarterly Rev Biophys

Primary Structure and Functional Expression of the 5HT3 Receptor, a Serotonin-Gated Channel

Science

The transmembrane domains of the nicotinic acetylcholine receptor contain alpha-helical and beta-structures

EMBO J

Chimaeric Nicotinic-Serotonergic Receptor Combines Distinct Ligand Binding and Channel Specificities

Nature

Potentiation of Nicotinic Receptor Response by External Calcium in Rat Central Neurons

Neuron

Calcium Modulation and High Calcium Permeability of Neuronal Nicotinic Acetylcholine Receptor

Neuron

Primary Structure and Functional Expression of the 5HT₃ Receptor, a Serotonin-Gated Channel