Original contributionBlockade of epinephrine priming of the cerebral auditory evoked response by cortical cholinergic deafferentation
Section snippets
Subjects
Subjects were adult male Sprague–Dawley rats (Harlan, Indianapolis, IN, USA), 90–120 days old at the time of surgery. Animals were housed in a temperature (73 °F) and humidity (45%) controlled colony on a 12:12 light/dark cycle (lights on a 6:30 AM). Food and water were available ad libitum. Animal care and use was in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals, and was approved by the Institutional Laboratory Animal Care and Use Committee
Histological results
As illustrated in Fig. 1, intra-basalis infusions of 192 IgG-saporin resulted in extensive cortical cholinergic deafferentation. Analysis of lesioned animals revealed greater than 95% loss of AChE-positive fibers bilaterally in most cortical areas, with almost no residual labeled fibers visible in the frontoparietal and temporal cortical regions (see Fig. 1). Similar to previous studies (e.g. McGaughy et al 1996, Turchi and Sarter 2000, the loss of cholinergic fibers in the cingulate,
Discussion
Results of the present study revealed that systemic epinephrine can modulate auditory processing as evidenced by an increase in amplitude of the major P70 component of the AER in control animals. Selective lesions of the basal forebrain cholinergic system were found to disrupt auditory processing as reflected in a delayed and attenuated P70. Finally, basal forebrain lesions were also found to block epinephrine enhancement of the AER. In view of the selectivity of the immunotoxin for basal
Acknowledgements
We thank Stephen J. McConoughey for assistance. This research was supported in part by a grant from the NHLBI (HL54428).
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