Functional blockade of the parabrachial area by tetrodotoxin disrupts the acquisition of conditioned taste aversion induced by motion-sickness in rats
Section snippets
Acknowledgements
This research was supported by the CICYT grants PB91-0735 and PB95-01182 (M.E.C. Spain). The authors are greatly indebted to J. Bures and O. Buresova for sharing non-published results, fruitful comments and seminal discussions on the topic.
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Cited by (22)
Evaluating proxies for motion sickness in rodent
2023, IBRO Neuroscience ReportsDorsal hippocampal damage disrupts the auditory context-dependent attenuation of taste neophobia in mice
2019, Neurobiology of Learning and MemoryCitation Excerpt :This indicates that the modulation of the taste memory by changing the auditory background was not specific for a single auditory frequency; the presentation order was counterbalanced and this had no effect (see Fig. 3) allowing one to conclude that the influence of auditory background is not unique to a particular tone and that this influence is specific to attenuation of neophobia, rather than a general disruption of drinking behavior (see Fig. 2A and B). Prior work has indicated a role for hippocampal function in complex taste learning phenomena, such as blocking (Gallo & Cándido, 1995; Moron et al., 2002) and in taste learning tasks that critically depend on contextual information (Gallo, Marquez, Ballesteros, & Maldonado, 1999). Electrolytic lesions of the dorsal hippocampus impaired both learned taste aversions to the physical context and the blocking of the context in taste aversion learning (Aguado, Hall, Harrington, & Symonds, 1998).
Fos induction in the amygdala by vestibular information during hypergravity stimulation
2003, Brain ResearchCitation Excerpt :This function of the amygdala might explain the fact that some susceptible individuals become sick, probably through a process of conditioning, on motionless vehicles or vessels. In fact, complex motion stimulation has been confirmed to be an effective aversive stimulus in conditioned taste aversion in rats [8,18]. Our results also showed that Fos protein induction in the CeA was still intense after a 24-h load of hypergravity, and then gradually decreased within 1 week (Fig. 2A).