Elsevier

Neuroscience Letters

Volume 251, Issue 3, 31 July 1998, Pages 189-192
Neuroscience Letters

IL-10 reduces rat brain injury following focal stroke

https://doi.org/10.1016/S0304-3940(98)00537-0Get rights and content

Abstract

The effects of the anti-inflammatory cytokine, IL-10, on brain injury following permanent focal ischemia were determined. Rats subjected to occlusion of the right middle cerebral artery (MCAO) were administered IL-10 (1 μg) centrally into the lateral ventricle 30 min and 3 h post MCAO or systemically into the tail vein (5 or 15 μg/h) starting 30 min post MCAO for 3 h. Brains were removed 24 h later and infarct size was measured. IL-10 administered centrally significantly (P<0.01) reduced infarct size by 20.7%±6.0 compared to vehicle. Systemic IL-10 administration at 5 and 15 μg/h significantly (P<0.05) decreased infarct size (40.3%±14.0 and 30.7%±13.7, respectively). These studies indicate that an anti-inflammatory therapeutic approach using IL-10 can provide neuroprotection in ischemic stroke.

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Acknowledgements

The authors gratefully acknowledge William J. Price for his technical assistance.

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