Studies on the antinociceptive effect of [Nphe1]nociceptin(1–13)NH2 in mice
Section snippets
Acknowledgements
We would like to thank G. Marzola (Pharmacology, University of Ferrara, Italy) for technical assistance and Dr D.G. Lambert (Anaesthesiology, University of Leicester, UK) for helpful discussion and proof-reading of the manuscript. This work was supported by founds from the University of Ferrara (60% grant to G.C.) and from the Italian Ministry of the University (Cofin 1999 grant to D.R.).
References (11)
- et al.
Effects of supraspinal orphanin FQ/nociceptin
Peptides
(2000) - et al.
Opiate tolerance and dependence: receptors
G-proteins, and antiopiates, Peptides
(1998) - et al.
Retro-nociceptin methylester, a peptide with analgesic and memory-enhancing activity
Life Sci.
(2000) - et al.
[Nphe(1)]nociceptin-(1–13)-NH(2) antagonizes nociceptin effects in the mouse colon
Eur. J. Pharmacol.
(1999) - et al.
Characterization of [Nphe(1)]nociceptin(1–13)NH(2), a new selective nociceptin receptor antagonist
Br. J. Pharmacol.
(2000)
Cited by (28)
In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations
2016, European Journal of PharmacologyCitation Excerpt :To investigate the receptor involved in the action of AT compounds in this preparation, knockout studies were performed. In line with previous studies (Di Giannuario et al., 2001) the action of N/OFQ was no longer evident in NOP(−/−) tissues while that elicited by the mu-selective agonist endomorphin-1 was unaffected or even increased. The effect of 1 µm Ro 65-6570 was only slightly and nonsignificantly reduced in NOP(−/−) tissue while that elicited by 0.1 µm of AT compounds was virtually abolished.
In vitro and in vivo pharmacological characterization of the nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-ol
2006, European Journal of PharmacologyNociceptin/orphanin FQ: Pain, stress and neural circuits
2005, Life SciencesTonic inhibition by orphanin FQ/nociceptin of noradrenaline neurotransmission in the amygdala
2004, European Journal of Pharmacology