Progress in Neuro-Psychopharmacology and Biological Psychiatry
Full length original paper experimental laboratory studySelectivity of action of typical and atypical antipsychotic drugs as antagonists of the behavioral effects of 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI)
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Use and abuse of dissociative and psychedelic drugs in adolescence
2021, Pharmacology Biochemistry and BehaviorCitation Excerpt :LSD, and other classic psychedelics, have overwhelmingly been shown to produce a biphasic response on exploratory behavior and locomotor activity, with an initial decrease, followed by an increase in behavior, in animal models (Adams and Geyer, 1982, 1985; Mittman and Geyer, 1991; Krebs-Thomson and Geyer, 1996; Krebs-Thomson et al., 1998; Ouagazzal et al., 2001; Pálenícek et al., 2010). The LSD-induced alterations in locomotor behavior are concomitant with a flat body posture, wet dog shakes, and head twitches (Pranzatelli, 1990; Fone et al., 1991; Wettstein et al., 1999). The alteration of locomotor behavior produced by LSD is commonly used as a proxy of human psychedelic response (for a detailed review, see (Hanks and Gonzalez-Maeso, 2013)).
Serotonin and serotonin receptors in hallucinogen action
2020, Handbook of Behavioral NeuroscienceComparative neuropharmacology of N-(2-methoxybenzyl)-2,5-dimethoxyphenethylamine (NBOMe) hallucinogens and their 2C counterparts in male rats
2018, NeuropharmacologyCitation Excerpt :Collectively, our behavioral findings demonstrate that NBOMe compounds display similar potency to induce shaking behaviors in rats and mice, with the NBOMes exhibiting at least 10-fold greater potency in vivo when compared to their 2C counterparts. Back muscle contractions, or BMC, are an established 5-HT2A-mediated behavior in rats but are not typically used to assess the in vivo effects of hallucinogens, likely due to the apparent absence of any comparable behavior in mice (Baumann and Rothman, 1996; Wettstein et al., 1999; Higgins et al., 2001). An additional goal of the current study was to assess the validity and utility of BMC as a behavioral read-out of 5-HT2A receptor activation in rats.
Recent advances in the neuropsychopharmacology of serotonergic hallucinogens
2015, Behavioural Brain ResearchPharmacological characterizations of memantine-induced disruption of prepulse inhibition of the acoustic startle response in mice: Involvement of dopamine D<inf>2</inf> and 5-HT<inf>2A</inf> receptors
2011, Behavioural Brain ResearchCitation Excerpt :The enhanced HTR was inhibited by i.p. administration of haloperidol or ketanserin [43]. Previous studies have demonstrated that haloperidol significantly attenuates 5-HT2A agonist DOI-induced HTR in mice [15,69]. It has been reported that haloperidol may act as an antagonist at 5-HT2 receptors [15,71].