International Journal of Immunopharmacology
The effect of nicotine on murine CD4 T cell responses
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In-vitro immunomodulatory effects of nicotine on Nitric Oxide, interleukin 1β and interleukin 37 production in human peripheral blood mononuclear cells (PBMC) from patients with Behçet disease
2021, International ImmunopharmacologyCitation Excerpt :In addition, other studies demonstrate that nicotine reduces secretion of pro-inflammatory cytokines such as IL-6, TNF-α, IL-12, IL-8, and IL-1β and alters NO levels in rats’ model of MS and in cultured human cells in-vitro [54,55,56,57]. In the same line, it was shown that nicotine increases IL-10 levels produced by splenic mononuclear cells isolated from female BALB/c mice and Rat Model of Multiple Sclerosis [58,53]. Specific receptors for nicotine are present on lymphocytes from human, rat, and mouse [59,60], and its anti-inflammatory effects are mediated through the activation of the alpha7 nicotinic acetylcholine receptor (α7nAChR) located on immune cells resulting in a decrease of pro-inflammatory cytokines production, particularly TNF-α and IL-2 from human monocytes cells [61], and IL1, IL-18 from human macrophages through an inhibitory effect on NF-κB activation [54].
Design, rationale, and baseline characteristics of a pilot randomized clinical trial of nicotine treatment for pulmonary sarcoidosis
2020, Contemporary Clinical Trials CommunicationsClinical implications of nicotine as an antimicrobial agent and immune modulator
2020, Biomedicine and PharmacotherapyInflammatory bowel disease: A key role for microbiota?
2020, Meta GeneAbnormal CD161<sup>+</sup> immune cells and retinoic acid receptor–related orphan receptor γt–mediate enhanced IL-17F expression in the setting of genetic hypertension
2017, Journal of Allergy and Clinical ImmunologyCitation Excerpt :In most hypertensive human subjects and animal models of hypertension, sympathetic nerve activity is exaggerated,61-63 an effect that can result in increased inflammatory responses. In contrast, the parasympathetic autonomic nervous system, through activation of α7-nAChR, exerts an anti-inflammatory effect on T cells.64-66 Activation of α7-nAChR expression on the surfaces of CD4+ T cells67 by nicotine reduces the TH17 response.68