Elsevier

Immunobiology

Volume 198, Issues 1–3, December 1997, Pages 35-49
Immunobiology

Regulation of NF-κB Activation by MAP Kinase Cascades

https://doi.org/10.1016/S0171-2985(97)80025-3Get rights and content

Abstract

Transcription factor NF-κB plays a crucial role in the regulation of numerous genes involved inthe inflammatory response and control of cell death. Activation of NF-κB is mediated through the phosphorylation of its inhibitory subunit IκB, followed by the subsequent degradation of IκB at the proteasome. A second level of control involves phosphorylation events of NF-κB in the cell nucleus. The kinases that regulate these processes are rather undefined. NF-κB activation is induced by a great variety of predominantly pathogenic and noxious stimuli. A similar spectrum of conditions triggers the activation of two mito gen-activated protein (MAP) kinase cascades, designated as the JNK and p38 kinase pathways. Several points of evidence suggest that MAP kinases can participate in the regulation of NF-κB transcriptional activity. Here, we will review very recent data demonstrating that both the JNK and the p38 pathways are involved in the activation of NF-κB in the cytoplasm as well as in modulation of its transactivating potential in the nucleus.

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    Dr. KLAUS SCHULZE-OSTHOFF, Department of Internal Medicine, Medical Clinics, Eberhard-Karls-University,Otfried-Müller-Str. 10, D-72076 Tübingen, FRG; Tel.: +49-7071-29 84113, Fax: +49-7071-29 5865

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