Role of the liver-enriched transcription factors C/EBPα and DBP in the expression of human CYP3A4 and CYP3A7
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Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism
2019, Archives of Biochemistry and BiophysicsCitation Excerpt :The methylation status of cytosine in the CYP3A4 and CYP3A7 proximal promoters was observed to correlate with changes in developmental expression of mRNA for the two enzymes [161]. The developmental expression of transcription factors (for instance PXR, CAR, Sp1/Sp3, USF1, NF1, HNF-3β, GR and C/EBP) as well as the interaction between these factors with the CYP3A7 promoter may contribute to the developmental expression pattern observed with the CYP3A7 gene [150,162–166]. The putative responsive motifs of transcription factors in the promoter region of CYP3A7 are shown in Fig. 2.
Hepatotoxicity of fusariotoxins, alone and in combination, towards the HepaRG human hepatocyte cell line
2017, Food and Chemical ToxicologyCitation Excerpt :Moreover, despite the increase of the expression levels of genes encoding for CYP3A4 and CYP4F3B after DON-ZEA combined exposure, the expression of the two transcription factors C/EBPα and HNF4α did not seem to be affected by the mixture. Yet, CYP3A4 is known to be under control of these two liver nuclear factors (Burk and Wojnowski, 2004; Ourlin et al., 1997). In differentiated HepaRG cells, Madec et al. (2011) observed a correlation between HNF4α activation and the regulation of CYP3A4 expression but not with CYP4F3B expression.
Sex-dependent regulation of hepatic CYP3A by growth hormone: Roles of HNF6, C/EBPα, and RXRα
2015, Biochemical PharmacologyCitation Excerpt :Hepatocyte nuclear factors (HNFs) and CCAAT/enhancer-binding protein (C/EBP) α have been considered to be the key transcription factors that collaborate with intracellular signalling molecules to mediate the sex-dependent effects of GH on liver gene expression [16]. Although HNF6 and C/EBPα have been reported to be involved in the regulation of CYP3A4 expression [17,18], the regulatory mechanism controlled by GH secretion is still largely unknown. Retinoid X receptor (RXR) α is an obligate partner for multiple nuclear receptors.
Developmental expression of drug metabolizing enzymes: Impact on disposition in neonates and young children
2013, International Journal of PharmaceuticsCitation Excerpt :Knowledge of specific mechanisms regulating drug metabolizing enzyme ontogeny is limited. There is some evidence that changes in transcription factor expression during development can have a role and in particular, HNF1α, C/EBPα, C/EBPβ, and PAR transcription factors (Ourlin et al., 1997; Edenberg, 2000; Martinez-Jimenez et al., 2005; Klick et al., 2008). However, other mechanisms likely will be involved.
The ontogeny of drug metabolism enzymes and implications for adverse drug events
2008, Pharmacology and TherapeuticsThe chimpanzee cytochrome P450 3A subfamily: Is our closest related species really that similar?
2007, Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics