Trends in Pharmacological Sciences
OpinionCocaine affects the dynamics of cytoskeletal proteins via sigma1 receptors
Section snippets
Interaction with sigma1 receptors
Now, it is known that sigma1 receptors and associated ligands, including cocaine and neurosteroids, can affect Ca2+ signaling at the ER in NG-108 cells 12 by causing the dissociation of a cytoskeletal adaptor protein ankyrin (specifically the ANK220 isomer) from the inositol (1,4,5)-trisphosphate [Ins(1,4,5)P3] receptors on the ER (Ref. 2) (Fig. 1). Ankyrins are proteins that interconnect spectrin-based cytoskeletons to membrane proteins and cell adhesion molecules, thus playing important roles
The role of Ca2+ in the life-long effects of cocaine
It is well known that [Ca2+]i plays important roles in cell differentiation and proliferation, and in the activation of transcription factors. Thus, although we hypothesize that cytoskeletal proteins might play important roles in the life-long action of cocaine, it is possible that Ca2+ might also play an important role in these effects. Indeed, [Ca2+]i can, via the activation of kinases 13, change the intrinsic activity and organization of cytoskeletal proteins, which suggests that a
Chemical name
NE100 N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]-ethylamine monohydrochloride
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