Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data
References (84)
- et al.
Physiologically based models and strategic experiments in hepatic pharmacology
Biochem. Pharmacol.
(1988) - et al.
Hepatic elimination of flowing substrates: the distributed model
J. Theor. Biol.
(1978) - et al.
Methotrexate pharmacokinetics
J. Pharm. Sci.
(1971) - et al.
Pharmacokinetics of 1-β-D-arabinofuranosylcytosine (Ara-C) deamination in several species
Biochem. Pharmacol.
(1973) - et al.
Human adult hepatocytes in primary monolayer culture. Maintenance of mixed function oxidase and conjugation pathways of drug metabolism
Biochem. Pharmacol.
(1987) - et al.
Stereoselective protein binding of verapamil enantiomers
Biochem. Pharmacol.
(1988) - et al.
Identification of cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes
Biochem. Pharmacol.
(1991) - et al.
Kinetic studies on the deethylation of ethoxybenzamide: a comparative study with isolated hepatocytes and liver microsomes of rat
Biochem. Pharmacol.
(1980) - et al.
The influence of the interdigestive migrating myoelectric complex on the gastric emptying of liquids
Gastroenterology
(1990) - et al.
Interspecies variability in mitoxantrone metabolism using primary cultures of hepatocytes isolated from rat, rabbit and human
Biochem. Pharmacol.
(1991)
Comparative drug metabolism of diazepam in hepatocytes isolated from man, rat, monkey and dog
Biochem. Pharmacol.
(1989)
Applications and prospects for physiologically based pharmacokinetic (PB- PK) models involving pharmaceutical agents
Toxicol. Lett.
(1995)
Models of hepatic drug clearance: discrimination between the “well-stirred” and “parallel-tube” models
J. Pharm. Pharmacol.
(1983)
Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4
Clin. Pharmacol. Ther.
(1989)
Prediction of intrinsic clearance of loxtidine from kinetic studies in rat, dog and human hepatocytes
Biochem. Soc. Trans.
(1990)
The distribution, metabolism and excretion of mexiletine in man
Postgrad. Med. J.
(1977)
Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance extrapolation of data to benzodiazepines and phenytoin
J. Pharmacokinet. Biopharm.
(1980)
Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics
J. Pharmacokinet. Biopharm.
(1982)
Mexiletine metabolism in vitro by human liver
Drug Metab. Dispos.
(1990)
Stereochemical aspects of warfarin in patients receiving chronic therapy
Br. J. Clin. Pharmacol.
(1984)
The role of mephenytoin 4′-hydroxylase in imipramine metabolism by human liver microsomes: a two enzyme kinetic analysis of N-demethylation and 2-hydroxylation
Br. J. Clin. Pharmacol.
(1994)
Role of cytochrome P4503A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor
Drug Metab. Dispos.
(1996)
Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers
Clin. Pharmacol. Ther.
(1988)
Animal scale-up
J. Pharmacokinet. Biopharm.
(1973)
Disposition of 14C-alprazolam, a new anxiolytic-antide-pressant, in man
Pharmacologist
(1980)
Lack of effect of cimetidine on the metabolism of quinidine: effect on renal clearance
Int. J. Clin. Pharmacol. Ther. Toxicol.
(1988)
Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction
Clin. Pharmacol. Ther.
(1992)
Predicting the hepatic clearance of xenobiotics in humans from in vitro data
Biopharm. Drug Dispos.
(1994)
Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese
Clin. Pharmacol. Ther.
(1989)
Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
Biochem. Pharmacol.
(1994)
Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s
J. Pharmacol. Exp. Ther.
(1990)
Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics
Biopharm. Drug Dispos.
(1996)
Binding of two adrenergic beta-receptor antagonists, alprenolol and H 93/26, to human serum proteins
Acta Pharm. Suec.
(1974)
The importance of substrate concentration in determining cytochromes P450 therapeutically relevant in vivo
Pharmacogenetics
(1994)
The tissue distribution, metabolism and excretion of lidocaine in rats, guinea pigs, dogs and man
J. Pharmacol. Exp. Ther.
(1972)
Inhibition of the enantioselective oxidative metabolism of metoprolol by verapamil in human liver microsomes
Drug Metab. Dispos.
(1992)
Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat
J. Pharmacol. Exp. Ther.
(1976)
Predictability of the in vivo metabolism of verapamil from in vitro data: contribution of individual metabolic pathways and stereoselective aspects
J. Pharmacol. Exp. Ther.
(1992)
Species similarities and differences in pharmacokinetics
Drug Metab. Dispos.
(1995)
Correlation between in vitro and in vivo drug metabolism rate: oxidation of ethoxybenzamide in rat
J. Pharmacokinet. Biopharm.
(1978)
Pharmacokinetics and metabolism of quinidine in extensive and poor metabolizers of sparteine
Eur. J. Clin. Pharmacol.
(1986)
Excretion of tolbutamide metabolites in young and old subjects
Eur. J. Clin. Pharmacol.
(1990)
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