The seminar is a personal overview and non-systematic synthesis analysis of articles published in English selected from a computer literature search (Medline/PubMed) over the past decade with the following key words: ulcerative colitis, Crohn's disease, and inflammatory bowel disease.
SeminarCrohn's disease
Section snippets
Interaction of genes, bacteria, and immunity
A simple cause and effect relation probably does not account for most cases of Crohn's disease. The pathogenesis of the disease is complex and consists of three interacting elements: genetic susceptibility factors, priming by the enteric microflora, and immune-mediated tissue injury.4, 5, 6 Experimental and observational data suggest that intestinal inflammation arises from abnormal immune reactivity to bacterial flora in the intestine of individuals who are genetically susceptible. Infectious
Therapeutic implications
A wide range of present and emerging drug treatments have been investigated for management of Crohn's disease.2, 3 Here, I discuss therapeutic implications of the more recent advances in pathogenesis.
Search strategy and selection criteria
References (62)
Inflammatory bowel disease: immunodiagnostics, immunotherapeutics and ecotherapeutics
Gastroenterology
(2001)Therapy of inflammatory bowel disease
Gastroenterology
(2000)Commensal bacteria as targets in Crohn's disease
Gastroenterology
(2000)- et al.
Inflammatory bowel disease and domestic hygiene in infancy
Lancet
(1994) - et al.
Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
Lancet
(2001) - et al.
Crohn's disease: genetic susceptibility, bacteria, and innate immunity
Lancet
(2001) - et al.
Animal models of mucosal inflammation and their relation to human inflammatory bowel disease
Curr Opin Immuol
(1999) The indigenous gastrointestinal microflora
Trends Microbiol
(1996)- et al.
Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease
Gastroenterology
(1998) - et al.
Give us this day our daily germs
Immunol Today
(1998)
Interleukin-12 and Th1 immune responses in human Peyer's patches
Trends Immunol
Suppression of T cell-mediated injury in human gut by interleukin 10: role of matrix metalloproteinases
Gastroenterology
T cells in inflammatory bowel disease: protective and pathogenic roles
Immunity
Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis
Gastroenterology
Odd forms of inflammatory bowel disease—what can they tell us?
Gastroenterology
High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy
Gastroenterology
Pharmacogenomics and metabolite measurement of 6-mercaptopurine therapy in inflammatory bowel disease
Gastroenterology
ANCA pattern and LTA haplotype relationship to clinical responses to anti-TNF antibody treatment in Crohn's disease
Gastroenterology
Ulcerative colitis and Crohn's disease: important and disabling diseases, still under-researched
BMJ
Enteric microflora in IBD: pathogens or commensals?
Inflamm Bowel Dis
Probiotics and inflammatory bowel disease: is there a scientific rationale?
Inflamm Bowel Dis
Measles virus and Crohn's disease: a critical appraisal of the current literature
Inflamm Bowel Dis
Tuberculosis asssociated with infliximab, a tumour necrosis factor α —neutralising agent
N Engl J Med
Mechanisms of immunologic sensation of intestinal contents
Am J Physiol
The genetic background of inflammatory bowel disease
Hepato-Gastroenterology
Genetics of inflammatory bowel disease: a puzzle with contradictions?
Gut
Genetics of inflammatory bowel disease: a reappraisal
Scand J Immunol
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Nature
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Nature
NF-κ B may determine whether epithelial cell-microbial interactions in the intestine are hostile or friendly
Clin Exp Immunol
Cited by (483)
Solidification and oral delivery of biologics to the colon- A review
2023, European Journal of Pharmaceutical SciencesAn indicator of Crohn's disease severity based on Turing patterns
2023, Chaos, Solitons and FractalsIsosteviol attenuates DSS-induced colitis by maintaining intestinal barrier function through PDK1/AKT/NF-κB signaling pathway
2023, International ImmunopharmacologyCitation Excerpt :Inflammatory bowel diseases (IBD) encompassing Crohn’s disease and ulcerative colitis are typically featured as chronic relapsing inflammation of the digestive tract [1,2].
8-Oxypalmatine, a novel oxidative metabolite of palmatine, exhibits superior anti-colitis effect via regulating Nrf2 and NLRP3 inflammasome
2022, Biomedicine and PharmacotherapyDiet, inflammation, and the “itises” (including musculoskeletal and gastrointestinal conditions)
2022, Diet, Inflammation, and Health