Allosteric proteins and cellular control systems

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The biological activity of many proteins is controlled by specific metabolites which do not interact directly with the substrates or products of the reactions. The effect of these regulatory agents appears to result exclusively from a conformational alteration (allosteric transition) induced in the protein when it binds the agent. It is suggested that this mechanism plays an essential role in the regulation of metabolic activity and also possibly in the specific control of protein synthesis.

References (55)

  • R. Benesch et al.

    J. Biol. Chem.

    (1961)
  • R.E. Benesch et al.

    J. Biol. Chem.

    (1961)
  • J.P. Changeux

    J. Mol. Biol.

    (1962)
  • G.T. Cori et al.

    J. Biol. Chem.

    (1938)
  • G.T. Cori et al.

    J. Biol. Chem.

    (1943)
  • E.H. Fischer et al.

    J. Biol. Chem.

    (1958)
  • C. Frieden

    J. Biol. Chem.

    (1959)
  • C. Frieden

    Biochim. biophys. Acta

    (1961)
  • C. Frieden

    Biochim. biophys. Acta

    (1962)
  • C. Frieden

    Biochim. biophys. Acta

    (1962)
  • C. Frieden

    J. Biol. Chem.

    (1962)
  • J.C. Gerhart et al.

    J. Biol. Chem.

    (1962)
  • F. Jacob et al.

    J. Mol. Biol.

    (1961)
  • A.B. Kent et al.

    J. Biol. Chem.

    (1958)
  • A. Lwoff et al.

    J. Theoret. Biol.

    (1962)
  • N.B. Madsen et al.

    J. Biol. Chem.

    (1956)
  • D.B. Martin et al.

    J. Biol. Chem.

    (1962)
  • J. Monod et al.

    Biochim. biophys. Acta

    (1951)
  • V.E. Morgan et al.

    J. Biol. Chem.

    (1935)
  • E.R. Stadtman et al.

    J. Biol. Chem.

    (1961)
  • H.E. Umbarger et al.

    J. Biol. Chem.

    (1958)
  • P.R. Vagelos et al.

    Biochem. Biophys. Res. Coram.

    (1962)
  • M. Waite et al.

    J. Biol. Chem.

    (1962)
  • J. Wolff

    J. Biol. Chem.

    (1962)
  • R.A. Yates et al.

    J. Biol. Chem.

    (1956)
  • K.L. Yielding et al.

    Biochim. biophys. Acta

    (1962)
  • J.P. Changeux
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