Original articleMetabolism of ethanol by rat pancreatic acinar cells☆
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2023, PancreatologyFatty acid ethyl ester (FAEE) associated acute pancreatitis: An ex-vivo study using human pancreatic acini
2020, PancreatologyCitation Excerpt :Alcohol consumption is one of the major risk factors of AP. The exocrine pancreas metabolises alcohol by both oxidative and non-oxidative (OME and NOME) pathways and non-oxidative ethanol metabolism generates fatty acid ethyl esters (FAEEs) [2–5]. Several studies reported that FAEE causes more injury than ethanol itself.
Chronic alcohol drinking: Liver and pancreatic cancer?
2015, Clinics and Research in Hepatology and GastroenterologyCitation Excerpt :Pharmacological inhibition of carboxylester lipase ameliorated the damaging effects of FAEE in isolated pancreatic acinar cells in vitro and in experimental model of acute alcoholic pancreatitis, illuminating a specific enzyme target for alcohol-induced injury [48]. Alcohol oxidative metabolism by cultured acinar cells was observed especially at higher concentration (50 mmol/L) as evidenced by the production of 14C-labeled acetate [49]. While acinar cells are predominant in pancreatic parenchyma, pancreatic stellate cells (PSC, a non-parenchymal cell type) may also be involved in alcohol metabolism.
Exposure to ethanol and tobacco smoke in relation to level of PCNA antigen expression in pancreatic and hepatic rat cells
2013, Pharmacological ReportsCitation Excerpt :However, pancreatic samples of addicted animals display only slightly derangements. Those differences between tissues probably were caused mainly by significantly less capacity for oxidative ethanol metabolism by the pancreas than that of the liver [24]. Other authors have demonstrated similar results that hepatic damage associated with chronic consumption of ethanol leads e.g., to an increase in the synthesis of fatty acids, triglycerides and biomarkers of oxidative stress, a decrease of fatty acids utilization and promotion of the infiltration of inflammatory leukocytes [10, 47].
Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with acute and chronic pancreatitis
2011, Experimental and Molecular PathologyCitation Excerpt :The comparison of the ADH isoenzyme activities in the pancreas showed that four classes of isoenzymes exist. Among the ADH isoenzymes the highest activity in the pancreas is represented by isoenzymes of class III (Chrostek et al., 2003; Haber et al., 1998). The activity of ADH I was very low and activities of class II and IV isoenzymes were barely detectable (Chrostek et al., 2003).
Ethanol enhances carbachol-induced protease activation and accelerates Ca<sup>2+</sup> waves in isolated rat pancreatic acini
2011, Journal of Biological Chemistry
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Supported by grants from the Gastroenterological Society of Australia; the Department of Veterans Affairs, Australia; the National Health and Medical Research Council of Australia; and the Ramaciotti Foundations.