Rapid communicationPeripheral blockade of topical morphine tolerance by ketamine
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Acknowledgements
This work was supported by a research grant from the National Institute on Drug Abuse (DA07242) to GWP. YAK was supported by a Clinical Investigator Award (DA00405) and GWP by a Senior Scientist Award (DA00220) from the National Institute on Drug Abuse.
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Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats
2013, PainCitation Excerpt :In addition, animals lacking DORs or the gene encoding preprotachykinin do not exhibit morphine tolerance [13,50]. Although the current study supports peripheral opioid tolerance [2,15,16,22,28], a previous finding showed that acute tolerance did not develop to the inhibitory effect of loperamide on herpetic allodynia in mice [30]. This discrepancy between these studies may be attributable to differences in the species and animal models, which could significantly affect the peripheral opioid tolerance that results from differences in neuropathic etiology and pathophysiology.
Blockade of NMDA Receptors Prevents Analgesic Tolerance to Repeated Transcutaneous Electrical Nerve Stimulation (TENS) in Rats
2008, Journal of PainCitation Excerpt :Thus, NMDA receptor antagonists, whether competitive or noncompetitive, prevent tolerance to exogenous opioids and to clinical treatments that use endogenous opioids. Systemic delivery of NMDA receptor antagonists prevents development of analgesic tolerance to μ- or δ-opioid agonists administered systemically,16,32,33 supraspinally,5,6,52 spinally,12,30 or peripherally.24,25 Therefore, the site of action of MK-801 in the current study could be supraspinal, spinal or peripheral.
Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception
2007, European Journal of PharmacologyPeripherally acting NMDA receptor/glycine<inf>B</inf> site receptor antagonists inhibit morphine tolerance
2005, NeuropharmacologyCitation Excerpt :However, such compounds may not be applicable to the inhibition of tolerance to morphine-induced antinociception which is believed to be primarily of central origin (McNally and Westbrook, 1998; McNally, 1999; Ueda and Inoue, 1999). On the other hand, recent data reported by Kolesnikov and colleagues demonstrated that local (topical) application of uncompetitive NMDA receptor antagonists, (+)MK-801 or ketamine, inhibited tolerance to topically applied morphine (Kolesnikov et al., 1996; Kolesnikov and Pasternak, 1999b; Kolesnikov and Pasternak, 1999a), suggesting a peripheral component of antinociceptive morphine tolerance. Since systemic rather than local administration of compounds is more favorable from the therapeutic perspective, the aim of the present study was to investigate whether antagonism of NMDA receptors in the peripheral nervous system (PNS) would inhibit tolerance to the antinociceptive effects of systemically administered morphine.