Rapid communication[Phe1ψ(CH2-NH)Gly2]nociceptin-(1-13)-NH2 is an agonist of the nociceptin (ORL1) receptor
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Acknowledgements
The authors thank the French Association pour la Recherche sur le Cancer (ARC 9428) and the European Commission (BMH4 CT97 2317) for financial support, and Dr. C. Topham for supervision of the English linguistic style.
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Central N/OFQ-NOP Receptor System in Pain Modulation
2016, Advances in PharmacologyCitation Excerpt :Initial studies reported that intracerebroventricular (i.c.v.) administration of N/OFQ produced hyperalgesia in the mouse hot plate and tail flick tests (Meunier et al., 1995; Reinscheid et al., 1995) and i.c.v. N/OFQ counteracted morphine-induced antinociception in the rodent tail flick test (King, Chang, & Pasternak, 1998; Tian et al., 1997). In addition, a peptidic analog of N/OFQ, [Phe1ψ(CH2-NH)Gly2]N/OFQ-(1–13)-NH2 (Butour, Moisand, Mollereau, & Meunier, 1998; Grisel, Farrier, Wilson, & Mogil, 1998), also elicited pronociceptive effects after i.c.v. administration in mice and rats, and inhibited morphine-induced antinociception in the mouse tail withdrawal assay (Calo et al., 1998; Wang, Zhu, Cao, & Wu, 1999b). Although exact mechanisms of NOP receptor agonist-induced pronociceptive effects are unclear, it is hypothesized that two types of neurons (ON cells and OFF cells) in the RVM, which regulate descending inhibition of pain, might be differentially regulated by the NOP receptor.
Anti-nociceptive and anti-allodynic effects of a high affinity NOP hexapeptide [Ac-RY(3-Cl)YRWR-NH<inf>2</inf>] (Syn 1020) in rodents
2007, European Journal of Pharmacology[Phe<sup>1</sup>psi(CH<inf>2</inf>-NH)-gly<sup>2</sup>]nociceptin-(1-13) -NH<inf>2</inf>
2007, xPharm: The Comprehensive Pharmacology ReferenceNociceptin antagonism: Probing the receptor by N-acetyl oligopeptides
2004, Regulatory Peptides