Morphine antinociception elicited from the ventrolateral periaqueductal gray is sensitive to sex and gonadectomy differences in rats

doi:10.1016/S0006-8993(98)01364-X

Brain Research

Volume 821, Issue 1, 6 March 1999, Pages 224-230

https://doi.org/10.1016/S0006-8993(98)01364-X Get rights and content

Abstract

Sex differences have been observed in antinociception following central administration of morphine into either the lateral ventricles or rostral ventromedial medulla (RVM) such that male rats exhibit significantly greater antinociception than female rats. The present study examined whether sex and adult gonadectomy differences were observed in morphine-induced (1–10 μg) antinociception elicited from the ventrolateral periaqueductal gray (vlPAG) on two nociceptive measures. Both sham-operated (ED₅₀=1.20–1.60 μg) and castrated (ED₅₀=1.08–1.09 μg) male rats displayed significantly greater magnitudes and potencies of morphine-induced antinociception on both tests than female rats. Sham-operated female rats tested during the estrous phase (ED₅₀=>50 μg) were significantly less sensitive to morphine than ovariectomized female rats (ED₅₀=1.98–2.51 μg). Thus, the vlPAG, a site sensitive to interactions between estradiol-containing hypothalamic loci and opioid peptides, elicits morphine-induced antinociception which is sensitive to sex differences and adult gonadectomy.

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Acknowledgements

This research was supported in part by PSC/CUNY Grants 668267 and 669256.

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Short communicationMorphine antinociception elicited from the ventrolateral periaqueductal gray is sensitive to sex and gonadectomy differences in rats

Abstract

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Acknowledgements

Neuropharmacology

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Short communication
Morphine antinociception elicited from the ventrolateral periaqueductal gray is sensitive to sex and gonadectomy differences in rats