Short communicationTime dependency of the action of nitric oxide in lipopolysaccharide–interferon-γ-induced neuronal cell death in murine primary neuron–glia co-cultures
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2013, Toxicology in VitroCitation Excerpt :However, astrocytes can be activated in response to brain injury from inflammation, damage or disease, and activated-astrocytes produce diverse inflammatory mediators, such as nitric oxide (NO), tumor necrosis factor-α (TNF-α) and reactive oxygen species (ROS) (Heales et al., 2004). Moreover, it is becoming increasingly clear that lipopolysaccharide (LPS), interleukin-1β (IL-1β) and interferon-γ (IFN-γ), when added to astrocyte cultures, stimulate nitric oxide synthase (iNOS) expression and NO generation enhancing the risk of neurodegenerative diseases including Parkinson’s disease (PD) (Jeohn et al., 2000; Koppula et al., 2012). Thus, modulation of astrocyte activation and inflammation may be an effective therapeutic approach against neurodegenerative diseases.
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