Regular paperClinical depression and inflammatory risk markers for coronary heart disease☆
Section snippets
Subjects:
A total of 100 adults were enrolled in the study; 50 of them met the diagnostic criteria for clinical depression, and the remaining 50 had no history of psychiatric illness. The groups were matched on a case-by-case basis with respect to age, gender, and ethnicity. All subjects were in good health, defined as having no history of chronic medical illness, no indications of acute infectious disease at study entry, as evidenced by a normal complete blood count, and no prescribed medication regimen
Results
Depressed and control subjects were very similar with respect to demographic features and cardiovascular risk factors (Table 1). The only exception to this was weight; depressed subjects weighed significantly more than controls (F [1, 98] = 6.84, p <0.01).
Discussion
The present study shows that in otherwise healthy adults, depression is accompanied by elevated levels of 2 inflammatory risk markers that have been implicated in CHD pathogenesis.10, 11, 20 These elevations are fairly large; on average, subjects with depression exhibited 41% higher CRP levels and 54% higher interleukin-6 levels than control subjects. Although an association between depression and inflammation has been reported,21, 22, 23, 24, 25 our study extends these findings by assessing
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This study was supported by a Grant-In-Aid from the American Heart Association, Dallas, Texas and a Veterans Administration Merit Review, St. Louis, Missouri.