Glutathione and related enzymes in multidrug resistance

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  • Cited by (224)

    • Platinum-resistant ovarian cancer: From drug resistance mechanisms to liquid biopsy-based biomarkers for disease management

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      Citation Excerpt :

      Elevated glutathione (GSH) levels are reported in several cancers including OC and linked with chemoresistance [30–32]. A high level of GSH in tumor cells is associated with increased expression and activity of GSH-related enzymes and exporter proteins, such as γ-glutamyl-cysteine ligase (GCL), γ-glutamyl-transpeptidase (GGT), and GSH-transporting export pumps [33,34]. GSH also has a high affinity toward platinum and forms cisplatin-thiol conjugates reducing cisplatin cytotoxicity [35].

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