Glutathione and related enzymes in multidrug resistance
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2021, Seminars in Cancer BiologyCitation Excerpt :Elevated glutathione (GSH) levels are reported in several cancers including OC and linked with chemoresistance [30–32]. A high level of GSH in tumor cells is associated with increased expression and activity of GSH-related enzymes and exporter proteins, such as γ-glutamyl-cysteine ligase (GCL), γ-glutamyl-transpeptidase (GGT), and GSH-transporting export pumps [33,34]. GSH also has a high affinity toward platinum and forms cisplatin-thiol conjugates reducing cisplatin cytotoxicity [35].
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