Apoptosis and signal transduction: clues to a molecular mechanism

https://doi.org/10.1016/0955-0674(93)90118-AGet rights and content

Abstract

Apoptosis, or programmed cell death, plays an essential role in specific cell deletion during normal embryonic and adult development in vertebrate and invertebrate species. Recent evidence suggests that signal transduction pathways governing cellular proliferation and cell cycle progression also mediate the physiological response to changes in the extracellular environment that trigger the anti-proliferatioe state characteristic of apoptosis.

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