Short communicationPeripherally administered IL-1α interferes with scopolamine-induced amnesia in mice
References (20)
- et al.
Pretreatment of young mice with nerve growth factor enhances scopolamine-induced hyperactivity
Dev. Brain Res.
(1986) - et al.
Reversal of scopolamine-induced amnesia by the GABA-B receptor antagonist CGP 35348 in the mouse
Cogn. Brain Res.
(1993) - et al.
Reduction of exploratory behavior by intraperitoneal injection of interleukin-1 involves brain corticotropin-releasing factor
Brain Res. Bull.
(1991) - et al.
Interleukin-1β inhibits long-term potentiation in the CA3 region of mouse hippocampal slices
Eur. J. Pharmacol.
(1990) Immunoregulators in the nervous system
Neurosci. Biobehav. Rev.
(1991)- et al.
Interleukin-1β decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats
Brain Res.
(1991) Functions and mechanisms of interleukin 1 in the brain
Trends Pharmacol. Sci.
(1991)- et al.
The cholinergic hypothesis of geriatric memory dysfunction
Science
(1982) - et al.
Metabolic and endocrine actions of interleukin-1. Effects on insulin-resistant animals
- et al.
Interleukin-2 enhances scopolamine-induced amnesia and hyperactivity in the mouse
NeuroReport
(1993)
Cited by (11)
Opiate modulation of IL-1α, IL-2, and TNF-α transport across the blood-brain barrier
2008, Brain, Behavior, and ImmunityCitation Excerpt :IL-1α, TNF-α, and IL-2 can have profound effects on the CNS. Peripherally administered IL-1 can alter feeding, sleep, glucose levels, thermogenesis, exploratory behavior, and cognitive functions (Banks et al., 2001; Bianchi and Panerai, 1993; Kent et al., 1992, 1996; Langhans and Hrupka, 1999; Spadaro and Dunn, 1990). TNF-α can induce proliferation of astrocytes, along with altering feeding and sleep (Krueger et al., 2001; Pan et al., 2004; Seihean et al., 2008; Shavit et al., 1986).
Blood-Brain Barrier Transport of Cytokines
2008, NeuroImmune BiologyCitation Excerpt :Thus, cytokines entering the blood stream from the CNS may have different effects, especially depending on which efflux route they use to enter the blood stream, than cytokines secreted directly into the blood from circulating immune cells or peripheral tissues. Cytokines produce a wide variety of effects on CNS function after either their central or peripheral administration [29–32]. The CNS effects of cytokines can be physiologic as in the case of TNF-mediated effects on physiologic sleep [33,34], adaptive as in the case of IL-1 induction of sickness behavior [35], or pathologic as in interferon gamma induction of depression [36] or IL-2 induction of stereotypic behavior [37].
Intravenous human interleukin-1 α impairs memory processing in mice: Dependence on blood-brain barrier transport into posterior division of the septum
2001, Journal of Pharmacology and Experimental Therapeutics