Elsevier

Cognitive Brain Research

Volume 1, Issue 4, December 1993, Pages 257-259
Cognitive Brain Research

Short communication
Peripherally administered IL-1α interferes with scopolamine-induced amnesia in mice

https://doi.org/10.1016/0926-6410(93)90009-TGet rights and content

Abstract

We studied the effects of human recombinant interleukin-1α on scopolamine-induced amnesia for a passive avoidance response in the mouse. Post-training intraperitoneal administration of the cytokine (0.25 or 0.50 μg/mouse) significantly reduced the amnesic effect of scopolamine (1.0 mg/kg i.p.). Our results indicate that peripheral interleukin-1α can influence behavior and suggest the involvement of the cholinergic system in the neuromodulatory actions of this cytokine.

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