Conference reviewProgress report on new antiepileptic drugs A summary of the Second Eilat Conference
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Cited by (45)
Therapeutic monitoring of antiepileptic drugs
2020, Handbook of Analytical SeparationsCitation Excerpt :Brivaracetam was recently approved for add-on in focal seizures. The most frequently reported side effects are drowsiness, tiredness, asthenia, and dizziness of mild to moderate severity with a dose-dependent increase in incidence, in addition to psychiatric symptoms as aggression in some patients [138,139]. Maybe this will be less pronounced with brivaracetam.
Comparative effectiveness of add-on therapy with newer-generation antiepileptic drugs in Bulgarian patients with refractory epilepsy
2018, Epilepsy and BehaviorCitation Excerpt :The main advantages of newer-generation AEDs, compared to conventional ones, are as follows: unique mechanisms of action, broad spectrum of action, similar efficacy, better pharmacokinetic characteristics (linear pharmacokinetics, lacking or lower enzyme induction, lower serum proteins binding, lower potential for drug interactions), better safety, and tolerability [1–13]. Effectiveness of all newer-generation AEDs as add-on treatment in patients with focal seizures has been confirmed by results from double-blind, randomized placebo-controlled, open prospective, and retrospective studies [14–43]. Some newer-generation AEDs have been proven as effective in generalized onset tonic–clonic seizures (lamotrigine, levetiracetam, topiramate, oxcarbazepine), atonic seizures (lamotrigine), absences (lamotrigine, topiramate), myoclonic seizures (lamotrigine, levetiracetam, topiramate), West syndrome, and Lennox–Gastaut syndrome (lamotrigine, topiramate, levetiracetam) [44–66].
A unified approach for detection of induced epileptic seizures in rats using ECoG signals
2013, Epilepsy and BehaviorCitation Excerpt :Epilepsy is a neurological disease that directly affects 50 million people worldwide [57]. In about two thirds of patients with epilepsy, seizures can be satisfactorily controlled with currently available antiepileptic drugs [58]. Another 8% can benefit from epilepsy surgery.
Antiepileptic Drugs: A Case Report in a Pregnancy With a Neural Tube Defect
2006, Pediatric NeurologyChapter 9 Therapeutic drug monitoring of antiepileptic drugs
2004, Handbook of Analytical SeparationsCitation Excerpt :Levetiracetam is effective in the treatment of partial seizures with or without generalisation to tonic clonic seizures [173]. The most frequently reported side effects are drowsiness, tiredness, asthenia, and dizziness of mild to moderate severity with a dose dependent increase in incidence [174,175]. The relationship between levetiracetam serum concentrations and clinical effect has not been ascertained and consequently, the value of serum concentration measurements has not been established.