Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures

doi:10.1016/0920-1211(90)90098-G

Epilepsy Research

Volume 7, Issue 2, November 1990, Pages 129-135

https://doi.org/10.1016/0920-1211(90)90098-G Get rights and content

Abstract

We report here the initial description of the inheritance pattern, linkage mapping, and electroclinical phenotype of a recessive mutation on mouse Chromosome 15, stargazer (stg), that produces epilepsy. The salient epileptic phenotype is a syndrome of spontaneous, prolonged, generalized spike-wave cortical discharges with behavioral arrest. A second, complex, seizure pattern featuring movements during the discharge can also appear. The stg/stg mutant phenotype confirms the general principal that inherited epilepsies sharing similar cortical excitability patterns can be transmitted by single gene loci residing on different chromosomes and provides new evidence that the severity of seizure expression depends on the specific mutant gene affected.

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Research reportStargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures

Abstract

Tables and a computer program for analyzing linkage data

Mouse News Letter

Catalog of mutant genes and polymorphic markers

Spontaneous polyspike discharges in an epileptic mutant mouse (Tottering)

Exp. Neurol.

Pathology of the spongiform encephalopathy in the Gray tremor mutant mouse

J. Neuropathol. Exp. Neurol.

Statistical Analysis in Biology

Mendelian Inheritance in Man

Genetic manipulation of ion channels: a new approach to structure and mechanism

Neuron

Analysis of inherited epilepsy using single locus mutations in mice

Research report
Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures