Journal of Chromatography B: Biomedical Sciences and Applications
High-performance liquid chromatographic method for the determination of nefazodone and its metabolites in human plasma using laboratory robotics
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2013, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :For the same biological samples, liquid chromatography using electrochemical (HPLC–ECD) [11], and ultraviolet (HPLC–UV) [12] detection has also been applied. Human plasma has been inspected for mCPP by HPLC–UV [13–17] and LC–MS [18]. The isomer has also been determined by HPLC–UV in human plasma, red blood cells [19] and plasma and breast milk [20].
High-throughput quantitation of nefazodone and its metabolites in human plasma by high flow direct-injection LC-MS/MS
2007, Journal of Pharmaceutical and Biomedical AnalysisElectrochemical characterisation of nefazodone hydrochloride and voltammetric determination of the drug in pharmaceuticals and human serum
2002, Analytica Chimica ActaCitation Excerpt :The widespread use of this compound and the need for clinical and pharmacological study require fast and sensitive analytical techniques to determine the presence of the drug in pharmaceutical formulations and serum samples. Up to now the most common techniques for the determination of the drug in commercial dosage form and biological fluids have been based on HPLC with UV detection [4–6] or with mass spectrometric detection [7,8] or coulometric detection [9] methods, but potentiometric method with ion-selective membrane electrode [10] has also been used. Electrochemical methods have proved to be very sensitive for the determination of organic molecules, including drugs and related molecules in pharmaceutical dosage forms and biological fluids [11–20].
LC determination and purity evaluation of nefazodone HCl in bulk drug and pharmaceutical formulations
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