Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE)
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Metabolism and physiologically based pharmacokinetic models
2020, Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk AssessmentSensitivity and Monte Carlo analysis techniques and their use in uncertainty, variability, and population analysis
2020, Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk AssessmentIncorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice
2018, Toxicology and Applied PharmacologyCitation Excerpt :The current model predictions for perc and TCA were also compared with MLE results of previous model. The current model predictions of the internal toxicokinetics of perc at both population and strain-specific levels are consistent with previous model predictions and in vivo data on perc and TCA in blood in male B6C3F1 mice at three different single doses of oil based oral gavage from Gearhart et al. (1993) (Fig. 6). The updated model at population level underestimated blood perc, especially at low dose (100 mg/kg) group, while it a bit overestimated blood TCA in the same dose group.
Modelling ecological and human exposure to POPs in Venice lagoon – Part II: Quantitative uncertainty and sensitivity analysis in coupled exposure models
2016, Science of the Total EnvironmentDevelopment and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans
2011, Toxicology and Applied PharmacologyCitation Excerpt :Reitz et al. (1996) performed in vitro and in vivo experiments to support their PBPK model in mice and rats, and used a “parallelogram approach” to estimate metabolic parameters in humans. Clewell et al. (2005) updated the Gearhart et al. (1993) model, including consideration of human toxicokinetic data published by Volkel et al. (1998). In addition, a number of PBPK models were developed only in humans, primarily to characterize uncertainty and/or human variability.
Evaluation of the impact of the exposure route on the human kinetic adjustment factor
2011, Regulatory Toxicology and Pharmacology