Histaminergic neuron system in the brain: Distribution and possible functions

doi:10.1016/0361-9230(91)90126-5

Brain Research Bulletin

Volume 27, Issues 3–4, September–October 1991, Pages 367-370

https://doi.org/10.1016/0361-9230(91)90126-5 Get rights and content

Abstract

Recent immunocytochemical studies have identified the histaminergic neuron system in the brain. In the rat brain, histaminergic neuronal cell bodies are located in the tuberomammillary nucleus in the posterior hypothalamus, while histaminergic fibers are distributed in almost all regions of the brain. Similar distributions of histaminergic neuronal cell bodies and fibers have been reported in the brains of other mammals and nonmammalian vertebrates. As expected from the widespread distributions of the efferent fibers, the central histaminergic neuron system seems to be involved in multiple functions in the brain. The results of intracerebral injection of histamine and administration of α-fluoromethylhistidine (FMH), which depletes brain histamine level, suggest that the central histaminergic system may modulate feeding, drinking and sexual behaviors, sleep-wakefulness and circadian rhythm, neuroendocrine and cardiovascular controls and thermoregulation.

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Citation Excerpt :
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NeurotransmittersHistaminergic neuron system in the brain: Distribution and possible functions

Abstract

Brain Res.

Prog. Neurobiol.

Brain Res.

Eur. J. Pharmacol.

Physiol. Behav.

Physiol. Behav.

Physiol. Behav.

Neuroscience

Neuropharmacology

Neuroscience

Neuroscience

Neuroscience

Brain Res.

J. Biol. Chem.

Brain Res.

Brain Res.

Neurosci. Lett.

Brain Res. Bull.

Neurosci. Lett.

Brain Res.

Brain Res.

Brain Res.

Neuroscience

The histaminergic system in the guinea pig central nervous system: immunocytochemical mapping study using an antiserum against histamine

J. Comp. Neurol.

Histaminergic system in the tree shrew brain

J. Comp. Neurol.

Comparative neuroanatomy of the histaminergic system in the brain of the frog Xenopus lavis

J. Comp. Neurol.

Development of histamine-immunoreactive neurons in the rat brain

J. Comp. Neurol.

A cytoarchitectonic atlas of the rat hypothalamus and third ventricle of the rat

Temperature changes following microinjection of histamine into the thermoregulatory centers of the rat

Experientia

Distribution of histaminergic neurons in the brain of the lamprey Lampetra fluviatilis as revealed by histamine-immunoreactivity

J. Comp. Neurol.

Nature of histaminergic neuromodulation of the release of the corticotropinergic system

Biogenic Amines

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Arch. Int. Pharmacodyn. Ther.

Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stern neurons

Acta Physiol. Scand.

Neurotransmitters
Histaminergic neuron system in the brain: Distribution and possible functions