Dorsal raphe, substantia nigra and locus coeruleus: Interconnections with each other and the neostriatum

doi:10.1016/0361-9230(77)90066-1

Brain Research Bulletin

Volume 2, Issue 5, September–October 1977, Pages 323-339

https://doi.org/10.1016/0361-9230(77)90066-1 Get rights and content

Abstract

Using a retrograde axonal transport method, direct projections to the neostriatum were demonstrated from the dorsal raphe nucleus, a large area of the ventral midbrain tegmentum (including the ventral tegmental area of Tsai, the substantia nigra pars compacta, reticulata and suboculomotoria), and the tegmentum ventral to the caudal red nucleus. A direct projection was also found from the mediodorsal part of the substantia nigra to the rostral part of the dorsal raphe nucleus. Projections from the entopeduncular nucleus (pallidum) and the lateral hypothalamic area to the lateral habenular nucleus, and from the latter to the dorsal raphe nucleus were also found. This habenular projection arises primarily from large neurons in the medial part of the lateral habenula and also from another group of small cells immediately adjacent to the medial habenular nucleus. A non-reciprocal connection of the dorsal raphe nucleus to the locus coeruleus was also found. On the basis of these results and the data available in the literature on the possible neurotransmitters used by these various structures, it is suggested that the dorsal raphe nucleus may play an important role in brain stem modulation of neostriatal function.

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^☆: Supported by NSF Grant BSN 74-02620, the Cultural Agreement between U.S.A. and Spain, and in part by Grant HD 06364.

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Dorsal raphe, substantia nigra and locus coeruleus: Interconnections with each other and the neostriatum☆

Abstract

Life Sci.

Brain Res.

Brain Res.

Brain Res.

Brain Res.

Brain Res.

Brain Res.

Electroenceph. Clin. Neurophysiol.

Brain Res.

Brain Res. Bull.

Brain Res.

Brain Res.

Brain Res.

Brain Res.

Expl Neurol.

Expl Neurol.

Efferent connections of the substantia nigra in the cat

Expl Neurol.

Locus coeruleus-to-dorsal raphe inputs examined by electrophysiological and morphological methods

Brain Res. Bull.

Treatment of Parkinson's disease with L-DOPA and Ro 4-4602. Review and present status

Anatomy of the basal ganglia and related nuclei: A review

Lesions of the substantia nigra in the rhesus monkey

Nigrostriatal and nigrothalamic fibers in the rhesus monkey

J. comp. Neurol.

Efferent fiber projections of the subthalamic nucleus in the rhesus monkey

Studi sulla struttura e sullo svilupo del mesen-cefalo

Arch. Ital. Anat. e di Embriol.

Serotonergic mechanisms and extrapyramidal function in man

The ascending efferent projections of the substantia nigra

Trans. Am. Neurol. Assoc.

Evidence for the existence of monoamine containing neurons in the central nervous system. 1. Demonstration of monoamines in the cell bodies of brain stem neurons

Acta physiol. scand.

Some ascending and descending projections of the substantia nigra and ventral tegmental area in the rat

Neuroscience Abstract

Biochemistry of the Basal Ganglia

Ascending projections of the substantia nigra in the rat

J. comp. Neurol.

Studies of the fiber connections of the substantia nigra in the rat using the method of retrograde transport of horseradish peroxidase

Neuroscience Abstracts

The connections of the pars suboculomotoria of the substantia nigra

Arch. Neurol. Psychiat.

Anatomie Cérébrale. Les noyaux gris centraux et la region mésencéphalo-sous-optiquc

The substantia nigra and the entopeduncular nucleus in the cat

J. comp. Neurol.

Evidence for the existence of monoamine neurons in the central nervous system. IV. Distribution of monoamine terminals in the central nervous system

Acta physiol. scand.

The effects of centrally acting drugs on tremor in monkeys with mesencephalic lesions