Atherosclerosis: the importance of HDL cholesterol and prostacyclin: a role for niacin therapy

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Abstract

Niacin reduces the incidence of non-fatal myocardial way infarction, confers a significant long-term survival benefit after recovery from myocardial infarction, and has had many years of study and usage by the medical community. Recent evidence suggests that via mechanisms which elevate HDL cholesterol and also release endogenous prostacyclin, niacin should be a potent agent in the long-term treatment of atherosclerosis.

References (40)

  • AL Willis et al.

    Effects of prostacyclin and orally active stable mimetic agent RS-93427007 on basic mechanisms of atherogenesis

    Lancet

    (1986)
  • G Rasmanis et al.

    Effects of intermittent treatment with aspirin on thromboxane and prostacyclin formation in patients with acute myocardial infarction

    Lancet

    (1988)
  • S Fischer et al.

    The prostacyclin/thromboxane balance is favorably shifted in Greenland Eskimos

    Prostaglandins

    (1986)
  • DM Small

    Progression and regression of atherosclerotic lesions: insights from lipid physical biochemistry

    Arteriosclerosis

    (1988)
  • DM Small et al.

    Physico-chemical and histological changes in the arterial wall of nonhuman primates during progression and regression of atherosclerosis

    J Clin Invest

    (1984)
  • RD Abbott et al.

    High density lipoprotein cholesterol, total cholesterol screening and myocardial infarction

    The Framingham Study. Arteriosclerosis

    (1988)
  • A Zampogna et al.

    Relationship between lipids and occlusive coronary artery disease

    Arch Intern Med

    (1980)
  • JF Brensike et al.

    Effects of therapy with cholestyramine on progression of coronary arteriosclerosis: Results of the NHLBI Type II Coronary Intervention Study

    Circulation

    (1984)
  • AC Arntzenius et al.

    Diet lipoproteins and the progression of coronary atherosclerosis: The Leiden Intervention Trial

    N Engl J Med

    (1985)
  • DH Blankenhorn et al.

    Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts

    JAMA

    (1987)
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