Nitric oxide targets in the guinea-pig intestine identified by induction of cyclic GMP immunoreactivity
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Autonomic neuromuscular junctions
2021, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :An example of a neurotransmitter whose action does not depend on a membrane potential change is nitric oxide (NO). NO is an inhibitory neurotransmitter in the gastrointestinal tract that diffuses across the smooth muscle cell membrane and activates soluble guanylate cyclase, thereby increasing levels of cyclic GMP, which relaxes the muscle by reducing cytoplasmic Ca2+ availability to the contractile apparatus (Young et al., 1993; Esplugues, 2002). The cell theory, that all organisms are composed of individual cells, was proposed in 1838 for plants by Matthias Schleiden and in 1839 for animals by Theodor Schwann.
NO-GC in cells ‘off the beaten track’
2018, Nitric Oxide - Biology and ChemistryCitation Excerpt :Clearly, these studies reveal an important role of NO-GC in adipocytes for fat development and energy homeostasis and indicate NO/cGMP signaling as therapeutic target for the treatment of obesity. In fact, liraglutide, a derivative of the human incretin glucagon-like peptide-1 was shown to upregulate NO-GC and PKG as well as BAT markers in mice and therefore, to induce browning of WAT [108]. As a note of caution, the importance of BAT-related thermogenesis as target for weight control is still being controversially discussed and its relevance regarding obesity is still not certain.
A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy
2016, American Journal of PathologyCitation Excerpt :Tissue from three randomly chosen sections of ileum and distal colon were graded by a blinded observer (J.B.F.) using a ×40 objective lens and 8-point graded scales (Table 1). Tissue for whole-mount immunohistochemistry analysis was opened along the mesenteric border and processed for immunohistochemistry analysis, as described previously,24 using the following primary antisera: rabbit anti-Kit (1:100; Merck Millipore, Bayswater, Australia), mouse anti–neuronal class III β-tubulin (1:2000; Covance Princeton, NJ), sheep anti–neuronal nitric oxide synthase (1:200025), and rat anti-F4/80 (1:5026). All primary antisera have been characterized previously.25,27–29
Heterogeneities in ICC Ca<sup>2+</sup> Activity Within Canine Large Intestine
2009, GastroenterologyCitation Excerpt :This is consistent with the observation that MPOs elicit action potentials more readily near the serosal surface of the LM,10 suggesting they could be generated by ICC-SERs. This is the first indication of a possible functional role of ICC-SERs, although these cells have been identified before in morphologic studies of the colon.23,24 In slow transit constipation, there is an increase in myenteric nitrergic neurons, but a decrease in cholinergic neurons,25 as well as increased NO production and a reduction in cholinergic responses.26
Interstitial cells of Cajal are innervated by nitrergic nerves and express nitric oxide-sensitive guanylate cyclase in the guinea-pig gastrointestinal tract
2008, NeuroscienceCitation Excerpt :The immunohistochemical localization of cGMP has been studied to determine potential physiological sites of action of NO in the GI musculature. cGMP production in ICC and FLC of guinea-pig intestine were reported in response to stimulation with NO donor, sodium nitroprusside (SNP) (Young et al., 1993). Exposure to SNP or nerve stimulation of canine colonic muscles caused cGMP production in ICC as well as neurons and smooth muscle cells (Shuttleworth et al., 1993).
Enteric Neural Regulation of Mucosal Secretion
2006, Physiology of the Gastrointestinal Tract