Opposite influences of dopaminergic pathways to the prefrontal cortex or the septum on the dopaminergic transmission in the nucleus accumbens. An in vivo voltammetric study

doi:10.1016/0306-4522(89)90331-X

Neuroscience

Volume 29, Issue 1, 1989, Pages 45-56

https://doi.org/10.1016/0306-4522(89)90331-X Get rights and content

Abstract

Modulation of dopaminergic transmission in the nucleus accumbens by the dopaminergic pathways reaching the prefrontal cortex (anteromedian and the suprarhinal parts) and the lateral septum was investigated. Changes in dopaminergic transmission in the nucleus accumbens were assessed by in vivo voltammetry using pretreated carbon fiber electrodes. This technique allows the selective detection of 3,4-dihydroxyphenylacetic acid, the main presynaptic metabolite of dopamine. Dopaminergic transmission in the prefrontal cortex (anteromedian and suprarhinal parts) and the lateral septum was altered by local injection of the dopaminergic agonist (d-amphetamine) and the dopaminergic antagonists (α-flupenthixol and sulpiride). Pharmacological interventions, either stimulation or blockade, in the anteromedian and suprarhinal parts of the prefrontal cortex induced, respectively, a decrease or an increase in extracellular 3,4-dihydroxyphenylacetic acid in the nucleus accumbens. The same pharmacological interventions in the lateral septum had exactly opposite effects in the nucleus accumbens. The inhibitory action of the mesocortical and mesorhinal dopaminergic projections and the facilitatory action of the mesoseptal dopaminergic projection on dopaminergic input in the nucleus accumbens were shown to rely on the activity of inhibitory fugal pathways which could be blocked by local injection of tetrodotoxin in the three structures. In a previous work, it was demonstrated that dopaminergic projections in the amygdala exert an inhibitory influence on dopaminergic transmission in the nucleus accumbens.

Thus the present results suggest that functional interdependence between the different dopaminergic pathways arising in the ventral mesencephalon is a general property of this neuronal group. Data obtained after manipulation of dopaminergic transmission in these various projection areas may need to be interpreted in a different light. Similarly, neurological and psychiatric observations may need to be reconsidered in view of the interdependence of the dopaminergic mesencephalic pathways.

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Opposite influences of dopaminergic pathways to the prefrontal cortex or the septum on the dopaminergic transmission in the nucleus accumbens. An in vivo voltammetric study

Abstract

The serotonin-producing neurons in the midbrain median and dorsal raphe nuclei

Selectivity of release of norepinephrine, dopamine and 5-hydroxytryptamine by amphetamine in various regions of the brain

Biochem. Pharmac.

The importance of neuronal uptake of amines for amphetamine-induced release of 3H-norepinephrine from isolated brain tissue

J. Pharmac. exp. Ther.

An autoradiographic examination of corticocortical and subcortical projections of the mediodorsal-projection (prefrontal) cortex in the rat

J. comp. Neurol.

Dopamine-containing systems in the CNS

Catecholaminergic brain stem regulatory systems

Behavioral and biochemical effects of dopamine and noradrenaline depletion within the medial prefrontal cortex of the rat

Brain Res.

Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes

A. Rev. Pharm. Toxicol.

An excitant amino acid projection from the medial prefrontal cortex to the anterior part of the nucleus accumbens in the rat

J. Neurochem.

Excitatory amino acid projections to the nucleus accumbens septi in the rat: a retrograde transport study utilizingd[3H]aspartate and [3H]GABA

Neuroscience

Regional and laminar density of the dopamine innervation in adult rat cerebral cortex

Neuroscience

Interconnections of the mesencephalic cell groups

Soc. Neurosci. Abst.

Converging projections from the mediodorsal thalamic nucleus and mesencephalic dopaminergic neurons to the neocortex in three species

J. comp. Neurol.

Nucleus locus ceruleus: new evidence of anatomical and physiological specificity

Physiol. Rev.

Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines

Neuroscience

In vivo electrochemical detection of catechols in the neostriatum of anaesthetized rats: dopamine or DOP AC

Nature, Lond.

Voltammetry in the striatum of chronic freely moving rats: detection of catechols and ascorbic acid

Brain Res.

Electrochemical pretreatment of pyrolytic carbon fiber electrodes

Analyt. Chem.

Enhanced amphetamine responses after frontal cortex lesions in the rat

Eur. J. Pharmac.

Behavioral implications of dopaminergic neurons in the mesolimbic system

Effect of haloperidol and sulpiride on dopamine metabolism in nucleus accumbens and olfactory tubercle: a study by in vivo voltammetry

Neuroscience

Effects ofd- andl-amphetamine on dopamine metabolism and ascorbic acid levels in nucleus accumbens and olfactory tubercle as studied by in vivo differential pulse voltammetry

Brain Res.

Modulation of dopaminergic activity in the nucleus accumbens following facilitation or blockade of the dopaminergic transmission in the amygdala: a study by in vivo differential pulse voltammetry

Brain Res.

Differential reactivity of dopaminergic neurons in the nucleus accumbens in response to different behavioral situations. An in vivo voltammetric study in free moving rats

Brain Res.

Presynaptic control of dopamine metabolism in the nucleus accumbens. Lack of effect of buspirone as demonstrated using in vivo voltammetry

Life Sci.

Limbic system basal ganglia and dopaminergic neurons: executive and regulatory neurons and their role in the organization of behavior

Brain Behav. Evol.

Electrophysiological responses of neurons of the ventral tegmental area to electrical stimulation of amygdala and lateral septum

Neuroscience

Catecholamine innervation of the basal forebrain. 1. The septal area

J. comp. Neurol.

Effects of unilateral microinjections of sulpiride into the medial prefrontal cortex on circling behavior of rats

Prog. Neuro-Psychopharmac. Biol. Psychiatr.