Quantitative light microscopic autoradiographic localization of cholinergic muscarinic receptors in the human brain: Forebrain
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Cortical layers: Cyto-, myelo-, receptor- and synaptic architecture in human cortical areas
2019, NeuroImageCitation Excerpt :However, the typical six-layered pattern of cytoarchitecture cannot be found in most receptor types; consequently, the borders between receptor-dense and receptor-sparse layers do not consistently coincide with the borders of layers detectable in cyto- or myeloarchitectonic studies. Rather, receptor densities seem to show a type- and region-specific layering pattern (Amunts et al., 2010; Caspers et al., 2013, 2015; Cortés et al., 1986, 1987; Eickhoff et al., 2007, 2008; Hoyer et al., 1986a,b; Jansen et al., 1989; Morosan et al., 2005; Palomero-Gallagher et al., 2008, 2009, 2013, 2015, Pazos et al., 1987a,b; Scheperjans et al., 2005a,b; Vogt et al., 2013; Zilles et al., 2002a, 2004, 2015a; Zilles and Amunts, 2009; Zilles and Palomero-Gallagher, 2001, 2017). Since most receptors are found on dendrites and not on the cell bodies of pyramidal cells and interneurons (Kooijmans et al., 2014), and the dendrites of pyramidal cells cross many cytoarchitectonically defined layers, the layering pattern of receptors is not bound to a single layer of cell bodies (cytoarchitecture) or myelinated nerve fibers (myeloarchitecture).
Cyto- and receptor architectonic mapping of the human brain
2018, Handbook of Clinical NeurologyCitation Excerpt :Nicotinic α4β2 receptors reach highest densities in the primary visual, auditory, and somatosensory cortices as well as in the motor, posterior cingulate, and entorhinal cortices (Fig. 24.5J). More detailed descriptions concerning the regional differences and laminar distribution patterns of muscarinic and nicotinic acetylcholine receptors can be found in the literature (Cortés and Palacios, 1986; Cortés et al., 1986, 1987; Lin et al., 1986; Araujo et al., 1988; Vanderheyden et al., 1990; Perry et al., 1992, 1993; Zilles, 1992, 2005; Court et al., 1993, 1997; Lange et al., 1993; Zilles et al., 1995, 1996, 2002a, b, 2003, 2004, 2015a; Geyer et al., 1997; Rodriguez-Puertas et al., 1997; Sihver et al., 1998; Crook et al., 2000, 2001; Marutle et al., 2001; Zilles and Palomero-Gallagher, 2001; Piggott et al., 2002; Morosan et al., 2004; Pimlott et al., 2004; Matsumoto et al., 2005; Scheperjans et al., 2005a, b; Eickhoff et al., 2007a, b, 2008; Palomero-Gallagher et al., 2008, 2009a, b, 2013; Palomero-Gallagher and Zilles, 2009; Zilles and Amunts, 2009, 2010; Amunts et al., 2010; Caspers et al., 2013c, 2015). Densities of α2-adrenoceptors in the cerebral cortex are generally lower than those of α1-adrenoceptors (Figs. 24.5K and L), with the notable exception of primary sensory areas (Scheperjans et al., 2005b; Eickhoff et al., 2007a; Zilles et al., 2015a; Zilles and Palomero-Gallagher, 2016), but are higher than those of β-adrenoceptors (Sastre et al., 2001).
Relationship between muscarinic M<inf>1</inf> receptor binding and cognition in medication-free subjects with psychosis
2018, NeuroImage: ClinicalCitation Excerpt :Moreover, regular treatment of Parkinson's disease with muscarinic receptor antagonists frequently induces cognitive deficits as an unwanted side effect (Xiang et al., 2012). These effects are to be predominantly mediated by the muscarinic M1 receptor subtype due to its high expression in critical regions for cognition (i.e., dorsolateral prefrontal cortex (DLPFC), hippocampus and striatum) (Cortes et al., 1987). Evidence for lower M1 receptor expression in psychotic disorders comes from post-mortem studies showing reduced expression rates of the M1 receptor subtype in the DLPFC.
Comparative Analysis of Receptor Types That Identify Primary Cortical Sensory Areas
2016, Evolution of Nervous Systems: Second EditionTransmitter Receptor Distribution in the Human Brain
2015, Brain Mapping: An Encyclopedic ReferenceHuman Brain Imaging of Acetylcholine Receptors
2014, Imaging of the Human Brain in Health and Disease