Elsevier

Neuroscience Letters

Volume 164, Issues 1–2, 24 December 1993, Pages 113-116
Neuroscience Letters

N-Methyl-d-aspartate receptors but not non-N-methyl-d-aspartate receptors mediate hypertension induced by carotid body chemoreceptor stimulation in the rostral ventrolateral medulla of the rat

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Abstract

In urethane-anesthetized rats, excitatory amino acid antagonists were microinjected into the rostral ventrolateral medulla (RVLM) and their effects on the pressor response and tachycardia evoked by carotid chemoreceptor stimulation were examined. Microinjections of the N-methyl-d-aspartate (NMDA) receptor antagonists 2-amino-5-phosphonovalerate (AP5) and MK-801 into the RVLM inhibited these chemoreceptor reflex responses whereas these responses were not affected by injection of the non-NMDA receptor antagonist CNQX. AP5 and MK-801 but not CNQX abolished the pressor response evoked by NMDA whereas CNQX but not AP5 and MK-801 abolished that evoked by AMPA or kainate. These results provide evidence that NMDA receptors in the RVLM of the rat are involved in the carotid chemoreceptor reflex.

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  • Sex differences in NMDA GluN1 plasticity in rostral ventrolateral medulla neurons containing corticotropin-releasing factor type 1 receptor following slow-pressor angiotensin II hypertension

    2015, Neuroscience
    Citation Excerpt :

    Microinjection of N-methyl-d-aspartate (NMDA) in the RVLM results in a pressor response in normal animals (Kagiyama et al., 2001; Takemoto, 2007) and spontaneously hypertensive rats show an exaggerated pressor response to RVLM NMDA administration (Lin et al., 2005). In addition, RVLM NMDA receptors have been shown to play an important role in the pressor response following carotid body chemoreceptor stimulation (Kubo et al., 1993) and muscle contraction (Reidman et al., 2000), as well as in the elevated blood pressure seen in rats with chronic heart failure (Wang et al., 2009) and in spontaneously hypertensive rats (Lin et al., 1995, 2005; Zhang and Abdel-Rahman, 2002). The obligatory GluN1 subunit of the heteromeric, ionotropic NMDA receptor (Dingledine et al., 1999) is expressed in the RVLM (Llewellyn-Smith and Mueller, 2013).

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