[Leu31-Pro34] neuropeptide Y identifies a subtype of 125I-labeled peptide YY binding sites in the rat brain
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2019, Pharmacology and TherapeuticsCitation Excerpt :It is involved in the regulation of decreased anxiety and depression (Caberlotto et al., 1999; Wahlestedt, Pich, Koob, Yee, & Heilig, 1993). The Y2 receptor is expressed in nerve fibers, the hippocampus, and intestine (Gehlert, Gackenheimer, & Schober, 1992; Rettenbacher & Reubi, 2001; Stjernquist & Owman, 1990), and it is associated with memory retention and angiogenesis (Flood & Morley, 1989; Zukowska-Grojec et al., 1998). The Y5 receptor is expressed in the hypothalamus, intestine, ovary, testis, pancreas, and skeletal muscle (Gerald et al., 1996; Herzog et al., 1997).
A cleavable cytolysin-neuropeptide Y bioconjugate enables specific drug delivery and demonstrates intracellular mode of action
2015, Journal of Controlled ReleaseCitation Excerpt :In a 96-well plate 5 × 104 cells were incubated with 125I-PYY (Perkin Elmer) at a final concentration of 60 pM (in 1% BSA/bidest. H2O (w/v), calculated based on specific radioactivity, corresponds to Kd [14]) and increasing concentrations of cold peptide (in 1% BSA/bidest. H2O (w/v)) for 60 min at room temperature under continuous shaking.
Co-expression of neuropeptide Y Y1 and Y5 receptors results in heterodimerization and altered functional properties
2007, Biochemical PharmacologyCitation Excerpt :HEK293 cells expressing the chimeric receptors and AV12 cells expressing the wild-type receptors stably, were washed once with phosphate-buffered saline (PBS) and pelleted in fresh PBS. Radioligand-binding assays were conducted on isolated crude membrane homogenates as previously described [18] using [125I]-PYY as radioligand. Nonspecific binding was defined as the amount of radioactivity remaining on the filter after incubating with 0.1 μM human PYY (Bachem).
Introduction to the reviews on neuropeptide Y
2004, Neuropeptides