Active secretion and enterocytic drug metabolism barriers to drug absorption
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2012, Saudi Pharmaceutical JournalCitation Excerpt :Also the attempts to define drug metabolism processes have been limited largely to various metabolic isoenzymes of the liver. Benet et al. (1996) and Wacher et al. (1996), were the first to hypothesize that for many drugs poor bioavailability could be due to the action of intestinal enzymes. They had performed certain cellular, animal and human studies and arrived at a conclusion that intestinal metabolic enzymes and efflux transporters working coordinately as a protective mechanism could be the cause for the poor bioavailability of certain drugs.
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